ArticleReviews in cardiovascular medicine2025
Metformin and Risks of Aortic Aneurysm and Aortic Dissection: A Mendelian Randomization Study.
Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies.Journal of advanced research · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous research has suggested that metformin may inhibit the dilation of an abdominal aortic aneurysm (AAA); however, these findings are controversial. Additionally, limited reporting exists on the relationships between metformin and thoracic aortic aneurysm (TAA) and aortic dissection (AD). Therefore, this study aimed to assess the potential relationship between metformin and the risk of aortic aneurysm (AA)/AD using the Mendelian randomization (MR) analysis. Methods: Genome-wide association studies and FinnGen summary data were utilized for the MR analysis. The causal relationship between metformin and AA/AD was primarily assessed using the inverse-variance weighted (IVW) method. Sensitivity analyses were conducted to detect heterogeneity and pleiotropy. Results: The results indicated a negative correlation between metformin treatment and the risk of both AA and AD, with odds ratios(ORs) reported as follows: OR = 0.010, 95% confidence interval (CI):0.000-0.212, Conclusions: This MR analysis identified a potential genetic causal relationship between metformin use and the risks of AA/AD, suggesting that metformin could serve as a protective agent in decreasing the incidences of these conditions.
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Registered trials
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