ArticleACS omega2025
Decreased Expression of Alzheimer's Disease-Related Genes in Cancer May Contribute to the Inverse-Relationship-a Computational Study.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Traditional Chinese Medicine and Ferroptosis in Alzheimer's Disease: A Potential Therapeutic Approach.Drug design, development and therapy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) has been largely prevalent among the older population. With the increasing incidence of cancer over the years, scientists have explored the relationship between these two conditions which were formerly associated with aging. Interestingly, an inverse relationship between cancer and AD has been observed in large cohort studies which has garnered substantial interest. While this inverse relationship presents a fascinating scientific puzzle, there is limited data on the molecular mechanisms that govern this phenomenon. This study aims to investigate the fundamental molecular mechanisms driving the inverse association between AD and three common cancers: breast, prostate, and colorectal cancers. Gene expression data for AD were obtained from the Gene Expression Omnibus (GEO) repository, specifically the GSE122063 data set. Differentially expressed genes (DEGs) between AD and nondemented controls were identified using the GEO2R tool. Genes associated with breast, prostate, and colorectal cancer were obtained from the Genecards database. Shared genes between cancers and AD-upregulated genes were identified using the Venny 2.1 tool. The UALCAN analysis portal was used to evaluate the mRNA expression of shared genes in cancer types. The DAVID tool, ShinyGO and SRplotter tools were used for functional enrichment analyses and gene ontology annotations. We found 20 genes upregulated in AD but significantly downregulated in breast cancer, 11 significantly downregulated in prostate cancer and 5 genes downregulated in colon cancer. Key genes were involved in pathways related to muscle structure, DNA repair, protein stability, and gene expression regulation. Three (3) of these genes,
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Registered trials
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