Evidence map›Paper›PMID 40352610›Full record

ArticleFrontiers in pediatrics2025

Longitudinal transcriptomic analysis of the hyperoxia-exposed preterm rabbit as a model of BPD.

Carlotta Boggi, Nicola Casiraghi, Xabier Murgia, Silvia Parolo, Enrica Scalera, Giorgio Aquila, Chiara Catozzi, Fabrizio Salomone, Francesca Stretti, Ilaria Minato and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carlotta BoggiDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Nicola CasiraghiFondazione the Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Xabier MurgiaScientific Consultancy, Bilbao, Spain.
Silvia ParoloFondazione the Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Enrica ScaleraDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Giorgio AquilaDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Chiara CatozziDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Fabrizio SalomoneDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Francesca StrettiDepartment of Veterinary Science, University of Parma, Parma, Italy.
Ilaria MinatoLaboratory of Biochemistry and Molecular Biology, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Francesca RavanettiDepartment of Veterinary Science, University of Parma, Parma, Italy.
Luisa RagionieriDepartment of Veterinary Science, University of Parma, Parma, Italy.
Roberta CiccimarraDepartment of Veterinary Science, University of Parma, Parma, Italy.
Matteo ZoboliDepartment of Veterinary Science, University of Parma, Parma, Italy.
Gino VillettiDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Barbara MontaniniLaboratory of Biochemistry and Molecular Biology, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Francesca RicciDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.
Matteo StortiDepartment of Experimental Pharmacology and Translational Science, R&D, Chiesi Farmaceutici S.P.A., Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is a multifactorial chronic lung disease of premature neonates. BPD development depends on prenatal and postnatal factors that induce inflammation, altering alveolar growth and pulmonary vascular development. Animal models are essential to investigate the precise molecular pathways leading to BPD. The preterm rabbit combines many advantages of small (e.g., rodents) and large BPD models (e.g., preterm lambs and baboons). Preterm rabbits display mild-to-moderate respiratory distress at delivery, which, along with continuous exposure to hyperoxia (95% O

Indexed as

bronchopulmonary dysplasiahyperoxiainflammationpreterm rabbitstranscriptomics

Identifiers

PMID40352610
PMCPMC12063497

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.