Evidence map›Paper›PMID 40354877›Full record

ReviewJournal of molecular and cellular cardiology2025

Cardiac macrophage: Insights from murine models to translational potential for human studies.

Yufeng Liu, Tricia T Wang, Yinsheng Lu, Muhammad Riaz, Yibing Qyang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yufeng LiuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department, New Haven, CT, USA; Yale Biological and Biomedical Sciences, Graduate School of Arts and Sciences, Yale University, New Haven, CT, USA.
Tricia T WangYale Biological and Biomedical Sciences, Graduate School of Arts and Sciences, Yale University, New Haven, CT, USA.
Yinsheng LuYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department, New Haven, CT, USA; Yale Stem Cell Center, New Haven, CT, USA; Department of Mechanical Engineering and Materials Science, Graduate School of Arts and Sciences, Yale University, New Haven, CT, USA.
Muhammad RiazYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Yibing QyangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, New Haven, CT, USA. Electronic address: yibing.qyang@yale.edu.

Funding

Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical CareR01HL150352 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2020 to 2023
$2.8M
Human tissue-engineered blood vessels using induced pluripotent stem cellsR01HL116705 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2013 to 2017
$2.0M
Readily Available Biological Conduits to Treat Single Ventricle DefectsR01HL171984 · NHLBI · YALE UNIVERSITY · PI Yibing Qyang · 2024 to 2026
$1.7M
Development of HLA engineered universal vascular grafts from human iPSCsR01HL155411 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2021 to 2024
$1.7M
Modulation of heart function by Muscle LIM protein-mediated mechanotransductionR01HL164783 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2022 to 2025
$1.7M
NHLBI NIH HHS R01 HL116705NHLBI NIH HHS R01 HL150352NHLBI NIH HHS R01 HL155411NHLBI NIH HHS R01 HL164783NHLBI NIH HHS R01 HL171984
6 · The paper itself

Abstract

Macrophages are a cell type that are known to play dynamic roles in acute and progressive pathology. They are highly attuned to their microenvironments throughout maturation, tailoring their functional responses according to the specific tissues in which they reside and their developmental origin. Cardiac macrophages (cMacs) have emerged as focal points of interest for their interactions with the unique electrical and mechanical stimuli of the heart, as well as for their role in maintaining cardiac homeostasis. Through an in-depth analysis of their origin, lineage, and functional significance, this review aims to shed light on cMacs' distinct contributions to both normal physiological maintenance as well as disease progression. Central to our discussion is the comparison of cMac characteristics between mouse and human models, highlighting current challenges and proposing novel experimental tools for deciphering cMac function within the intricate human cardiac microenvironments based on current murine studies. Our review offers valuable insights for identifying novel therapeutic targets and interventions tailored to the distinct roles of these immune cells in cardiovascular diseases (CVDs).

Indexed as

MacrophagesMyocardiumTranslational Research, BiomedicalAnimalsCardiovascular DiseasesDisease Models, AnimalHumansMiceCardiac macrophageCardiovascular diseasesHumanMacrophage functionMacrophage originMouse

Identifiers

PMID40354877
PMCPMC12162190

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.