ArticleBMJ open2025
Associations between multiple acute infarctions and intracranial arterial stenosis with functional outcomes in anterior circulation acute ischaemic stroke reperfusion therapy: results from the China National Stroke Registry III.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to observe the correlation between infarction pattern and intracranial arterial stenosis (ICAS) on magnetic resonance and functional outcome in acute ischaemic stroke (AIS) patients after reperfusion therapy.
designThis is a post hoc analysis of the Third China National Stroke Registry (CNSR-III) study.
settingThe data was derived from the CNSR-III study, which was a nationwide clinical registry of ischaemic stroke or transient ischaemic attack based in China.
participantsPatients with anterior circulation AIS who underwent reperfusion therapy were included for analysis. The patients were divided into single acute infarction and multiple acute infarctions (MAIs) based on the diffusion-weighted imaging findings. Additionally, patients were categorised according to the degree of ICAS assessed by magnetic resonance angiography as either ≥50% or <50%. PRIMARY OUTCOME MEASURES: The primary outcome of this study was poor functional outcome at 12 months, defined as a modified Rankin Scale of 3-6.
resultsIn the included 796 patients, there were 152, 130 and 126 cases of unfavourable functional outcomes at 3 months, 6 months and 12 months, respectively. After adjusting for all potential confounding factors, MAIs were significantly associated with an increased risk of poor functional outcomes at 12 months (OR 1.96; 95% CI 1.27 to 3.02; p=0.0024). Similarly, ≥50% ICAS was also correlated with an increased risk of poor functional outcomes (OR 1.74; 95% CI 1.14 to 2.67; p=0.0110).
conclusionsBoth MAIs and ≥50% ICAS were associated with poor functional outcomes in patients with anterior circulation AIS who received reperfusion therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.