Evidence map›Paper›PMID 40355555›Full record

ArticleThe EMBO journal2025

Aldolase-regulated G3BP1/2

Esteban Quezada, Klaus-Peter Knoch, Jovana Vasiljevic, Annika Seiler, Akshaye Pal, Abishek Gunasekaran, Carla Münster, Daniela Friedland, Eyke Schöniger, Anke Sönmez and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Esteban QuezadaMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID http://orcid.org/0009-0008-9123-4430
Klaus-Peter KnochMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Jovana VasiljevicMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Annika SeilerMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Akshaye PalMax Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
Abishek GunasekaranMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-7221-4863
Carla MünsterMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Daniela FriedlandMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Eyke SchönigerMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Anke SönmezMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Pascal RochMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Carolin WegbrodMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Katharina GanßMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Nicole KipkeMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Simon AlbertiBiotechnology Center (BIOTEC), Center for Molecular and Cellular Bioengineering, TU Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0003-4017-6505
Rita NanoDiabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Lorenzo PiemontiDiabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Daniela AustDepartment of Pathology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden Germany, TU Dresden, Dresden, Germany.
Jürgen WeitzPaul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Marius DistlerPaul Langerhans Institute Dresden (PLID) of the Helmholtz Center Munich at the University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Michele SolimenaMolecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany. michele.solimena@tu-dresden.de.ORCID http://orcid.org/0000-0002-3653-8107

Funding

Deutsche Forschungsgemeinschaft (DFG) SO 818/10-1Innovative Medicines Initiative 2 Joint Undertaking (RHAPSODY) 115881INTERCEPT-T2D 101095433
6 · The paper itself

Abstract

Upregulation of insulin mRNA translation upon hyperglycemia in pancreatic islet β-cells involves several RNA-binding proteins. Here, we found that G3BP1, a stress granule marker downregulated in islets of subjects with type 2 diabetes, binds to insulin mRNA in glucose concentration-dependent manner. We show in mouse insulinoma MIN6-K8 cells exposed to fasting glucose levels that G3BP1 and its paralog G3BP2 colocalize to cytosolic condensates with eIF3b, phospho-AMPKα

Indexed as

Fructose-Bisphosphate AldolaseInsulinInsulin-Secreting CellsPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA, MessengerRNA Recognition Motif ProteinsAnimalsCell Line, TumorDNA HelicasesGlucoseHumansMiceDNA HelicasesFructose-Bisphosphate AldolaseG3BP1 protein, humanG3bp1 protein, mouseGlucoseInsulinPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA, MessengerRNA Recognition Motif ProteinsDiabetesInsulinIsletStress GranulesTranslation

Identifiers

PMID40355555
PMCPMC12216156

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.