Evidence map›Paper›PMID 40355758›Full record

ArticleNature aging2025

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging.

Seyed Soheil Saeedi Saravi, Benoit Pugin, Florentin Constancias, Khatereh Shabanian, Marianne Spalinger, Aurélien Thomas, Sylvain Le Gludic, Taraneh Shabanian, Gergely Karsai, Manuel Colucci and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
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  3. Review
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  5. Article
  6. Review
  7. Article
  8. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
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  19. Frontiers in immunology · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Seyed Soheil Saeedi Saravi *Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland. soheil.saeedi@uzh.ch.ORCID http://orcid.org/0000-0001-6227-8049
Benoit PuginLaboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Florentin ConstanciasLaboratory of Food Biotechnology, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Khatereh ShabanianCenter for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
Marianne SpalingerDepartment for Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Aurélien ThomasFaculty Unit of Toxicology, University Center of Legal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6790-2285
Sylvain Le GludicFaculty Unit of Toxicology, University Center of Legal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Taraneh ShabanianCenter for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
Gergely KarsaiInstitute of Clinical Chemistry, University Hospital Zurich, Schlieren, Switzerland.ORCID http://orcid.org/0000-0002-6840-682X
Manuel ColucciInstitute of Oncology Research (IOR), Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-4955-5416
Cristina MenniDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London, UK.ORCID http://orcid.org/0000-0001-9790-0571
Ilias AttayeDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London, UK.
Xinyuan ZhangDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London, UK.ORCID http://orcid.org/0000-0001-9472-9641
Meret Sarah AllemannCenter for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.ORCID http://orcid.org/0000-0002-9840-6089
Pratintip LeeCenter for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Alessia ViscontiDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London, UK.
Mario FalchiDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London, UK.ORCID http://orcid.org/0000-0002-5646-1004
Andrea AlimontiInstitute of Oncology Research (IOR), Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-9362-2313
Frank RuschitzkaCenter for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
Francesco PaneniCenter for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland.
Jürg H Beer *Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland. hansjuerg.beer@ksb.ch.ORCID http://orcid.org/0000-0002-7199-0406

Funding

Novartis Stiftung für Medizinisch-Biologische Forschung (Novartis Foundation for Medical-Biological Research) #21A053Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) #310030_21A053Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) #CRSK-3_229134Wellcome Trust
6 · The paper itself

Abstract

Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (PAGln), are elevated in aged humans and mice. Metagenomic analyses reveal an age-related increase in PAA-producing microbial pathways, positively linked to the bacterium Clostridium sp. ASF356 (Clos). We demonstrate that colonization of young mice with Clos increases blood PAA levels and induces endothelial senescence and angiogenic incompetence. Mechanistically, we find that PAA triggers senescence through mitochondrial H

Indexed as

AgingCellular SenescenceEndothelial CellsGastrointestinal MicrobiomePhenylacetatesAgedAnimalsClostridiumFecesFemaleGlutamineHumansHydrogen PeroxideMaleMiceMice, Inbred C57BLGlutamineHydrogen PeroxidePhenylacetatesphenylacetic acidphenylacetylglutamineSirtuin 1

Identifiers

PMID40355758
PMCPMC12176623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.