ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Study partner characteristics moderate the prediction of cognitive decline in aging.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Study partners' views on remuneration in longitudinal Alzheimer's disease research.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Study partner characteristics moderate the prediction of cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Racial and ethnic differences in informant reports of cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Effects of care partner type on outcomes from a multicomponent behavioral intervention for mild cognitive impairment.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
5 authors.
Funding
Abstract
introductionWe investigated whether study partner characteristics moderated the ability of informant measures to predict cognitive decline in a cognitively unimpaired sample.
methodsData were from 2164 cognitively unimpaired participants from the National Alzheimer's Coordinating Center and their study partners. Composite cognition scores were calculated at baseline and first follow-up. Linear mixed models tested whether prediction of cognitive change from informant-dependent measures (Functional Activities Questionnaire [FAQ], Neuropsychiatric Inventory Questionnaire [NPI-Q], and Clinical Dementia Rating Scale Sum of Boxes [CDR-SB]) was moderated by study partner characteristics (i.e., demographics, relationship, cohabitation, duration known, frequency of visits and calls).
resultsPrediction of cognitive decline from FAQ and NPI-Q, but not CDR-SB, was more accurate for study partners who were cohabitants and spouses/partners versus others. There were no other significant moderations. DISCUSSION: Information from cohabitant and spousal study partners better predicted cognitive decline, but effects were modest and may not warrant stringent inclusion criteria for study partners. HIGHLIGHTS: Study partners provide information about participant functioning in AD studies. Study partner characteristics moderated the utility of informant-dependent measures. Ratings from spousal and cohabitant study partners best predicted cognitive decline. Study partner demographics, duration known, and frequency of contact had no effects. These moderators had modest effect sizes in this cognitively unimpaired sample.
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