ReviewDevelopmental medicine and child neurology2025
Developmental and epileptic encephalopathy with spike-wave activation in sleep: From the 'functional ablation' model to a neurodevelopmental network perspective.
Review in Developmental medicine and child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Diagnostic Challenges and Consideration of Landau-Kleffner Syndrome as a Differential Diagnosis for Language Disorders: A Case Report.Clinical case reports · 2025Article
- Developmental and epileptic encephalopathy with spike-wave activation in sleep: From the 'functional ablation' model to a neurodevelopmental network perspective.Developmental medicine and child neurology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between epilepsy and cognition is intricate and multifaceted, particularly in the context of childhood-onset epileptic disorders where epileptic activity can significantly interfere with and disrupt the delicate, highly plastic, and environment-related trajectories of neurodevelopment. Developmental and epileptic encephalopathy with spike-wave activation during slow sleep (D/EE-SWAS), a spectrum of conditions including Landau-Kleffner syndrome, could serve as a valuable model to explore these complexities. Research to date has primarily examined its distinctive features, including genetic and structural etiological factors, electroencephalographic patterns, and cognitive phenotypes, often interpreted through simplified cause-effect paradigms. The adoption of a network perspective that aligns with neurodevelopmental trajectories is essential to grasp the full complexity of this evolving condition. Advancing research requires the integration of multimodal data, while leveraging tools such as artificial intelligence to develop sophisticated models in order to achieve a holistic understanding of D/EE-SWAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.