Evidence map›Paper›PMID 40356340›Full record

ReviewFEBS open bio2025

The role of circular RNAs in regulating cytokine signaling in cancer.

Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vandana JoshiDepartment of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, India.
SwatiDepartment of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, India.
Amit MishraCellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, India.ORCID https://orcid.org/0000-0001-9401-4400
Amaresh PandaInstitute of Life Science (ILS), Bhubaneswar, India.
Vivek SharmaDepartment of Biological Sciences, Birla Institute of Technology and Science Pilani, Hyderabad Campus, India.ORCID https://orcid.org/0000-0001-7345-4597

Funding

Indian Council of Medical Research 2021-10878
6 · The paper itself

Abstract

Dysregulation of cytokine signaling is central to the development and progression of cancer. Cytokines are not only involved in promoting cancer development but also regulate anti-tumor immune responses. Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules lacking free ends, which have emerged as critical regulators of cytokine signaling. Transcriptional and post-transcriptional regulation of cytokine signaling by circRNAs contributes to cancer pathogenesis. Here, we discuss the emerging role of circRNAs in modulating cytokine signaling pathways that regulate cancer development. In particular, we examine the role of circRNAs in TGF-β, IL-6, IL-10, TNF-α, VEGF, FGF, PDGF, and chemokine signaling in cancer.

Indexed as

CytokinesNeoplasmsRNA, CircularSignal TransductionAnimalsGene Expression Regulation, NeoplasticHumansCytokinesRNA, Circularcancerchemokinescircular RNAscytokinesTGF‐βVEGF

Identifiers

PMID40356340
PMCPMC12401181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.