ReviewCureus2025
Bacterial Histamine as a Therapeutic Target for Abdominal Pain in Irritable Bowel Syndrome: A Literature Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, altered bowel habits, and discomfort. This narrative review explores the current understanding of IBS pathophysiology, diagnosis, and treatment, with a focus on the role of histamine in gastrointestinal disorders. The review summarizes the existing literature from electronic databases and manual searches. Key topics covered include the diagnostic criteria for IBS, mechanisms underlying abdominal pain, role of histamine in gastrointestinal motility, visceral hypersensitivity, and immune system dysregulation, highlighting its potential as a therapeutic target in IBS management. The narrative synthesis of findings provides insights into the complex interplay between gut microbiota, histamine production, and IBS symptomatology. Overall, this review underscores the need for further research to elucidate the mechanisms underlying IBS and histamine-related gastrointestinal disorders, with the ultimate goal of developing tailored therapeutic interventions for individuals affected by these conditions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.