Evidence map›Paper›PMID 40357771›Full record

ReviewCurrent topics in medicinal chemistry2026

Traditional Chinese Medicines for Alzheimer's Disease: Current Knowledge, Clinical Applications, and Future Directions.

Yu Deng, Chaojun Chen, Hongtao Li, Tianle Wang, Xu Zhang, Xueyang Wang, Guangtao Pan

Abstract readReview
In one paragraph

Review in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu DengGuangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Chaojun ChenDepartment of Neurology, Guangzhou Hospital of Integrated Traditional and West Medicine Affiliated to Guangzhou University of Chinese Medicine, Guangzhou 510800, Guangdong, China.
Hongtao LiFirst Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China.
Tianle WangGuangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Xu ZhangGuangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China.
Xueyang WangYancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, 224000, Jiangsu, China.
Guangtao PanYancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, 224000, Jiangsu, China.

Funding

Fund of Young Scientific and Technological Talents Support Project by Jiangsu Association for Science and Technology TJ-2022-097General Program of Natural Science Foundation of Guangdong Province 2019A1515011668
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses a significant challenge to the health of the global aging population. Despite extensive research, the complex mechanisms underlying AD pathogenesis remain largely elusive. In recent years, a growing number of clinical studies have demonstrated the preventive and therapeutic potential of Traditional Chinese Medicine (TCM) against AD through multiple pathways, targets, and compounds. In this study, we conducted a review of the literature published over the past 20 years through international and domestic databases, including PubMed, Medline, Cochrane Library, CNKI, SinoMed, Wanfang, and VIP Journal Integration Platform. This review systematically evaluates current research advancements regarding single-herb preparations, bioactive constituents, and compound formulations in Traditional Chinese Medicine (TCM), with focused analysis on three therapeutic categories: tonifying herbs, blood-activating and stasis-eliminating agents, as well as orifice-opening, phlegm-resolving, and mind-stabilizing medicinal substances. Furthermore, this review discusses the potential mechanisms underpinning the anti-AD effects of TCMs. By integrating these insights, this review aims to establish a theoretical foundation for the application of TCMs in AD treatment and provide a reference for future pharmacological studies and the development of health-related products.

Indexed as

Alzheimer DiseaseDrugs, Chinese HerbalMedicine, Chinese TraditionalNeuroprotective AgentsAnimalsHumansDrugs, Chinese HerbalNeuroprotective AgentsAlzheimer's diseaseResearch progress.Traditional chinese medicineTraditional chinese medicine compound recipes

Identifiers

PMID40357771
PMCPMC13312403

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.