Other lipid agents × lipids

TrialClinical cardiology2025

Lipid-Lowering Effect and Safety of Ezetimibe and Atorvastatin 5 mg in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia: A Randomized, Double-Blind, Parallel, Multicenter, Phase 3 Clinical Trial.

You-Jeong Ki et al.PubMed ↗Full text ↗Publisher ↗

  • Low-intensity atorvastatin (5 mg) plus ezetimibe (10 mg) combination therapy (A5E10)looks good hereLower LDL-C reduction, no range given.No ranges given.

What the trial testedas reported · 2025

No range given

Reported lower LDL-C reduction, no range given

−47.6percentage points

low-intensity atorvastatin (5 mg) plus ezetimibe (10 mg) combination therapy (A5E10) vs atorvastatin 5 mg [A5]

As reported

difference −47.6 %, no interval

+1 more in the walkthrough ↓

Who was studied, and how

252people in the A Randomized, Double Blind, Parallel, Multi-center, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of DW1125 and DW1125A in Patient With Primary Hypercholesterolemia or Mixed Dyslipidemia trial, from 2022
of them with dyslipidemia, aged 19+, in this paper

The trial randomly assignedassigned by chance

low-intensity atorvastatin (5 mg) plus ezetimibe (10 mg) combination therapy (A5E10)
atorvastatin 5 mg [A5]

Reported lower LDL-C reduction, no range given−47.6

randomised

the abstract, start to end

significantly greater LDL-C reduction (47.6%) compared with A5 (33.4%), E10

was observed over the 4 weeks, with a 46.7% reduction in LDL-C levels

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
LDL-C reductionlow-intensity atorvastatin (5 mg) plus ezetimibe (10 mg) combination therapy (A5E10) vs atorvastatin 5 mg [A5]
−47.6
LDL-C levelslow-intensity atorvastatin (5 mg) plus ezetimibe (10 mg) combination therapy (A5E10)
−46.7
StatinsOther lipid agentsLipids

Other lipid agents × lipidshelps?mixed

unlikelylikely
0.500.50 without it

Statins × lipidshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 7

1 paper cites it

2025
2026
this papercites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 40357888