Evidence mapPaperPMID 40358166Full record

ArticleCells2025

Prolactin Mediates Distinct Time Course Regulation of Tyrosine Hydroxylase Phosphorylation and Gene Expression in Tuberoinfundibular Dopaminergic Neurons of Female Rats.

Philip J Jensik, Lydia A Arbogast

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Philip J JensikDivision of Molecular and Integrative Physiology, Department of Biomedical Science, Southern Illinois University School of Medicine, Carbondale, IL 62901-6523, USA.ORCID 0000-0001-6726-1510
Lydia A ArbogastDivision of Molecular and Integrative Physiology, Department of Biomedical Science, Southern Illinois University School of Medicine, Carbondale, IL 62901-6523, USA.ORCID 0000-0002-5307-3946

Funding

Prolactin Feedback to Hypothalamic Dopaminergic NeuronsR01HD045805 · NICHD · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI ARBOGAST, LYDIA A · 2005 to 2009
$1.7M
Opioid-Dopamine Interactions During LactationR01HD048925 · NICHD · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI ARBOGAST, LYDIA A · 2005 to 2009
$1.3M
NICHD NIH HHS R01 HD045805NICHD NIH HHS R01 HD048925NIH HHS HD045805NIH HHS HD048925
6 · The paper itself

Abstract

Prolactin (PRL) regulates its own secretion by short-loop feedback to tuberoinfundibular dopaminergic (TIDA) neurons. PRL-induced cellular mechanisms in the regulation of tyrosine hydroxylase (TH) are not completely understood. The objectives were to (1) examine PRL-induced, time-dependent hypothalamic changes in JAK2-STAT5B signaling, TH activity, TH phosphorylation state and

Indexed as

Dopaminergic NeuronsGene Expression RegulationProlactinTyrosine 3-MonooxygenaseAnimalsFemaleJanus Kinase 2PhosphorylationPromoter Regions, GeneticRatsRats, Sprague-DawleySignal TransductionSTAT5 Transcription FactorTime FactorsJak2 protein, ratJanus Kinase 2ProlactinSTAT5 Transcription FactorTyrosine 3-Monooxygenasedopaminegene expressionJAK2phosphorylationprolactinprolactin receptor signalingpromoter activitySTAT5TIDAtyrosine hydroxylase

Identifiers

PMID40358166
PMCPMC12071785

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.