Evidence map›Paper›PMID 40358181›Full record

ArticleCells2025

Effect of Recombinant Human Amelogenin on the Osteogenic Differentiation Potential of SHED.

Akira Hirabae, Ryo Kunimatsu, Yuki Yoshimi, Kodai Rikitake, Shintaro Ogashira, Ayaka Nakatani, Shuzo Sakata, Kotaro Tanimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akira HirabaeDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Ryo KunimatsuDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0002-5016-4957
Yuki YoshimiDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0001-7845-983X
Kodai RikitakeDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Shintaro OgashiraDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Ayaka NakataniDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Shuzo SakataDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Kotaro TanimotoDepartment of Orthodontics, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.ORCID 0000-0003-4439-1579

Funding

Japan Society for the Promotion of Science 22K10247Japan Society for the Promotion of Science 24K02654JST SPRING none
6 · The paper itself

Abstract

This study aimed to explore how amelogenin can improve stem cells from human exfoliated deciduous teeth (SHED)-based bone regeneration and promote tissue healing as a treatment for critical-sized bone defects. SHED was induced into bone differentiation by using osteogenic differentiation medium. Real-time polymerase chain reaction, alkaline phosphatase (ALP) staining and quantification, and Alizarin Red S staining, as well as calcium and osteocalcin quantification were performed to assess differentiation. On day 18, a significant increase was observed in the expression of

Indexed as

AmelogeninCell DifferentiationOsteogenesisRecombinant ProteinsTooth, DeciduousAlkaline PhosphataseBone RegenerationCalciumCells, CulturedHumansOsteocalcinAlkaline PhosphataseAmelogeninCalciumOsteocalcinRecombinant ProteinsamelogenincalcificationMSCsosteoblast differentiationrh174SHED

Identifiers

PMID40358181
PMCPMC12071429

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.