ArticleBiochemistry2025
G Protein Selectivity in Dopamine Receptors is Determined before GDP Release.
Caesar Tawfeeq, Ari S Hilibrand, Jeffrey S Smith, Jennifer Portillo, Andrew C Kruse, Ravinder Abrol
Abstract read
In one paragraphArticle in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
6 authors.
Caesar TawfeeqDepartment of Chemistry and Biochemistry, California State University, Northridge, California 91330, United States.
Ari S HilibrandDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Jeffrey S SmithDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Jennifer PortilloDepartment of Chemistry and Biochemistry, California State University, Northridge, California 91330, United States.
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0002-1467-1222 Ravinder AbrolDepartment of Chemistry and Biochemistry, California State University, Northridge, California 91330, United States.ORCID 0000-0001-7333-6793 Funding
BUILD PODER IITL4GM118977 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHAVIRA, GABRIELA, KHACHIKIAN, CRIST SIMON · 2015 to 2023
$18.1MMaking antibody generation rapid, scalable, and democratic through machine learning and continuous evolutionR01CA260415 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KRUSE, ANDREW, LIU, CHANG C · 2020 to 2024
$8.4MProject-002UL1GM118976 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI SAETERMOE, CARRIE L · 2015 to 2023
$7.8MBiochemical Determinants of Chemokine Receptor SignalingK08AR084617 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey SCOTT Smith · 2024 to 2026
$502kStructural dynamics and energy landscapes of G protein signalingR16GM153621 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI Ravinder Abrol · 2024 to 2026
$443kProbing the Structural Basis of Innate G Protein Specificity in G Protein-Coupled Receptor SignalingSC2GM130480 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI ABROL, RAVINDER · 2020 to 2022
$435kNCI NIH HHS R01 CA260415NIAMS NIH HHS K08 AR084617NIGMS NIH HHS R16 GM153621NIGMS NIH HHS SC2 GM130480NIGMS NIH HHS TL4 GM118977NIGMS NIH HHS UL1 GM118976
6 · The paper itselfAbstract
Dopaminergic signaling in neurophysiological processes utilizes multiple G proteins. The dopamine receptor subtypes D1R/D5R selectively couple to G
Indexed as
GTP-Binding ProteinsGuanosine DiphosphateReceptors, Dopamine D1Receptors, Dopamine D2GTP-Binding Protein alpha Subunits, Gi-GoHumansMolecular Dynamics SimulationProtein BindingThermodynamicsGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding ProteinsGuanosine DiphosphateReceptors, Dopamine D1Receptors, Dopamine D2
Identifiers
PMID40358213
PMCPMC12138965
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390