ArticleACS applied materials & interfaces2025
Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/Ti
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research.Journal of nanobiotechnology · 2026Review
- Evaluating Complexity in Orthopedic Tissue-on-a-Chip Systems.Advanced healthcare materials · 2026Review
- A review of the wide applications of microfluidic devices in peri-implantitis, periodontitis, and endodontics.Odontology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly osseointegrative dental implants surrounded by reconstructed periodontal tissues represent a promising strategy for functional tooth replacement, as they mimic the structural and physiological characteristics of natural teeth. However, there is currently a lack of in vitro platforms that can effectively evaluate the integration of engineered periodontal ligament (PDL) tissues with bioimplants. In this study, we developed a bioimplant-on-a-chip (BoC) platform designed to recapitulate the native PDL-cementum interface and assess the early stage biological performance of bioimplants in vitro. The BoC consists of a dental implant, a calcium phosphate cement (CPC) insert, a nanopatterned polydimethylsiloxane (PDMS) substrate, and PDL-like tissue derived from human dental pulp stem cells (DPSCs). To establish viable culture conditions within the platform, surface coatings and cell seeding densities were optimized to support the formation of PDL-like tissue. Nanogrooved substrates were incorporated to guide cellular alignment, which was assessed through orientation analysis. Collagen fiber organization and matrix deposition were further examined as indicators of ligamentous tissue maturation. Cementogenic activity was evaluated by immunofluorescent staining of cementum protein-1 (CEMP-1) in response to varying biogenic hydroxyapatite (bHA) contents in the bioimplants. The results demonstrated successful reproduction of a PDL-like tissue interface and material-dependent differences in CEMP-1 expression. This platform provides a modular and reproducible tool for the comparative evaluation of bioimplants in a physiologically relevant setting and may be useful in advancing regenerative strategies in dental implantology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.