Evidence map›Paper›PMID 40359935›Full record

ArticleCell genomics2025

Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features.

Yerin Kim, Luke Saville, Kieran O'Neill, Jean-Michel Garant, Yilin Liu, Simon Haile-Merhu, Maryam Ghashghaei, Quang Anh Hoang, Amber Louwagie, Yongjin P Park and 2 more

Abstract read
In one paragraph

Article in Cell genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Comprehensive Profiling of NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Long-Read Sequencing Reveals RNA Splicing Complexity in Human Diseases.Computational and structural biotechnology journal · 2026
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yerin KimTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Bioinformatics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Canada's Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 0B4, Canada.
Luke SavilleTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Kieran O'NeillCanada's Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 0B4, Canada.
Jean-Michel GarantCanada's Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 0B4, Canada.
Yilin LiuTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Department of Experimental Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Simon Haile-MerhuCanada's Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 0B4, Canada.
Maryam GhashghaeiFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Quang Anh HoangTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Amber LouwagieTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Yongjin P ParkFaculty of Statistics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, Vancouver, BC V5Z 0B4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: sjones@bcgsc.ca.
Ly P VuTerry Fox Laboratory, BC Cancer Research Institute, Vancouver, BC V5Z 0B4, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: lvu@bccrc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification and functional characterization of chemical modifications on an mRNA molecule, in particular N

Indexed as

Nanopore SequencingRNA, MessengerRNA Processing, Post-TranscriptionalSequence Analysis, RNATranscriptomeAdenosineAlternative SplicingCell Line, TumorHumansMethyltransferasesPolyadenylationRNA StabilityAdenosineMethyltransferasesMETTL3 protein, humanN-methyladenosineRNA, Messengerepitranscriptomicslong-read sequencingmRNA decaynanopore direct RNA sequencingnative RNA sequencingpoly(A) tail lengthRNA featuresRNA methylationRNA processingRNA splicing

Identifiers

PMID40359935
PMCPMC12230237

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.