ReviewSeminars in nephrology2025
Plasma Neutrophil Gelatinase-Associated Lipocalin as a Biomarker of Kidney Injury and Potential Predictor of Hypoxic Brain Injury in Severe Plasmodium falciparum Malaria: Insights From India.
Review in Seminars in nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.Malaria journal · 2026Pooled it
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Severe malaria is associated with kidney and brain injury, yet potential mechanisms linking both complications remain understudied. We investigated the associations between kidney and brain injuries in a cohort of Indian adults and children with severe Plasmodium falciparum malaria. We found that acute kidney injury was prevalent in both adults (64.4%) and children (71.4%). We also found that plasma levels of the structural kidney injury biomarker neutrophil gelatinase-associated lipocalin (NGAL) were strongly associated with acute kidney injury severity (P < .0001) and negatively correlated with whole brain magnetic resonance imaging apparent diffusion coefficient values in cerebral malaria (r = -0.6, 95% confidence interval, -0.8 to -0.3). Low apparent diffusion coefficient values indicate cytotoxic edema, a form of hypoxic brain injury mediated by parasite sequestration and inflammation. Severe cytotoxic edema has been shown to be associated with increased mortality in severe malaria. In our cohort, there was a 5.5-fold greater risk of this form of brain injury (prevalence risk ratio, 5.5, 95% confidence interval, 2.3-13.2) in patients with high NGAL levels (>300 ng/mL). These results suggest that plasma NGAL may play a critical role in structural kidney injury and could serve as a predictive marker for hypoxic brain injury in the context of severe malaria.
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