Evidence map›Paper›PMID 40360488›Full record

ArticleNature communications2025

Control of spatiotemporal activation of organ-specific fibers in the swine vagus nerve by intermittent interferential current stimulation.

Nicolò Rossetti, Weiguo Song, Philipp Schnepel, Naveen Jayaprakash, Dimitrios A Koutsouras, Mark Fichman, Jason Wong, Todd Levy, Mohamed Elgohary, Khaled Qanud and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  7. Article
  8. Article
  9. Decoding Pain: Next-Generation In Vitro Systems for Mechanistic Insights and Drug Discovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Nicolò Rossetti *imec, Eindhoven, Netherlands.
Weiguo Song *Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.
Philipp Schnepel *imec, Eindhoven, Netherlands.
Naveen JayaprakashInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.
Dimitrios A Koutsourasimec, Eindhoven, Netherlands.ORCID http://orcid.org/0000-0002-9456-9630
Mark Fichmanimec, Eindhoven, Netherlands.
Jason WongInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.
Todd LevyInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.ORCID http://orcid.org/0000-0003-0440-7791
Mohamed ElgoharyInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.
Khaled QanudInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.ORCID http://orcid.org/0000-0003-2943-1245
Alice GiannottiSant'Anna School of Advanced Study, Pisa, Italy.ORCID http://orcid.org/0000-0002-3208-1971
Mary F BarbeTemple University School of Medicine, Philadelphia, PA, USA.
Frank Liu ChenTemple University School of Medicine, Philadelphia, PA, USA.
Geert Langereisimec, Eindhoven, Netherlands.ORCID http://orcid.org/0000-0002-0354-4447
Timir Datta-ChaudhuriInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA.ORCID http://orcid.org/0000-0001-7377-1939
Vojkan Mihajlovićimec, Eindhoven, Netherlands.
Stavros ZanosInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research and Northwell Health, Manhasset, NY, USA. szanos@northwell.edu.ORCID http://orcid.org/0000-0002-3967-8164

Funding

RECONSTRUCTING VAGAL ANATOMY75N98022C00019 · OD · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ZANOS, STAVROS · 2022 to 2024
$6.8M
Selective, Epineural Stimulation of Peripheral Nerves with Interferential Electrical FieldsR01NS136685 · NINDS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Stavros Zanos · 2025 to 2026
$1.2M
NIH HHS 75N98022C00019NINDS NIH HHS R01 NS136685U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01NS136685-01U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) 75N98022C00019-P00003-9999-1
6 · The paper itself

Abstract

Vagus nerve stimulation (VNS) is emerging as potential treatment for several chronic diseases. However, limited control of fiber activation, e.g., to promote desired effects over side effects, restricts clinical translation. Towards that goal, we describe a VNS method consisting of intermittent, interferential sinusoidal current stimulation (i

Indexed as

Nerve FibersVagus NerveVagus Nerve StimulationAction PotentialsAnimalsLaryngeal MusclesLungSwineX-Ray Microtomography

Identifiers

PMID40360488
PMCPMC12075724

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.