Evidence map›Paper›PMID 40360955›Full record

ArticleMolecular neurobiology2025

Association of GRM7 Polymorphisms with Bilateral Auditory Regions Glutamate and Coupling with Glutathione in ARHL Patients.

Jing Wang, Fuyan Li, Fuxin Ren, Wen Ma, Yuxi Liu, Wenjing Zhang, Xi Li, Yanfei Bi, Qian Xin, Fei Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing WangDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Fuyan LiDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Fuxin RenDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Wen MaDepartment of Otolaryngology, The Central Hospital of Jinan City, Shandong University, Jinan, China.
Yuxi LiuDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Wenjing ZhangDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Xi LiDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Yanfei BiDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China.
Qian XinCentral Laboratory, The Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. xinqian@sdu.edu.cn.
Fei GaoDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-Wu Road, Jinan, 250021, China. feigao@email.sdu.edu.cn.

Funding

National Natural Science Foundation of China No. 81601479Postdoctoral innovation project of Shandong Province No. SDCX-ZG-202303058Postdoctoral innovation project of Shandong Province No. SDCX-ZG-202400047Shandong Provincial Natural Science Foundation of China Nos. ZR2021MH030Shandong Provincial Natural Science Foundation of China Nos. ZR2021MH355Taishan Scholars Project of Shandong Province No. tstp20240525
6 · The paper itself

Abstract

This study aimed to investigate the relationship between GRM7 polymorphisms and the levels of glutamate (Glu) and glutathione (GSH) in bilateral auditory regions (ARs) of ARHL patients. Seventy-eight ARHL patients (mean age, 65.94 years ± 3.37 [SD]; 44 men) and 46 normal hearing (NH) controls (mean age, 65.72 years ± 2.32 [SD]; 28 men) were enrolled. Glu and GSH levels in bilateral ARs of all participants were measured and estimated by using magnetic resonance spectroscopy (MRS) and LCModel. In addition, we collected peripheral venous blood samples from all participants for DNA extraction and investigated polymorphisms in the GRM7 gene using TaqMan SNP genotyping. The results showed that Glu and GSH levels in bilateral ARs were significantly lower in GRM7 high-risk group compared with GRM7 low-risk group, regardless of disease status (all p

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseGlutamic AcidGlutathionePolymorphism, Single NucleotideReceptors, Metabotropic GlutamateAgedFemaleHumansMaleMiddle AgedGlutamic AcidGlutathionemetabotropic glutamate receptor 7Receptors, Metabotropic GlutamateARHLAuditory region (AR)GluGRM7GSH

Identifiers

PMID40360955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.