ArticleBMC geriatrics2025
The association of hemopexin, muscle quality, and sarcopenia in Japanese older adults with cognitive impairment: a cross-sectional study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A systematic review of the association between phase angle and cognitive function among older adults.GeroScience · 2026Review
- Longitudinal study on the relationship between extracellular water distribution changes and muscle mass in severe sarcopenia patients using multi-frequency bioelectrical impedance analysis combined with phase angle measurements.European geriatric medicine · 2026Article
- Tracking hemopexin intracellularly and defining hemopexin protein "interactomes" in human immune and liver cell models.Frontiers in physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo examine the cross-sectional associations of hemopexin, muscle quality, and sarcopenia status with cognitive function among older Japanese adults with cognitive impairment, and to explore the potential sex-specific differences.
methodsA total of 580 older adults (372 women, 208 men; mean age 83.3 ± 6.2 years) who presented with cognitive impairment at the Kyoto Dementia Comprehensive Center between 2018 and 2022 were enrolled. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Hemopexin level was measured by enzyme-linked immunosorbent assay. Muscle quality was evaluated via phase angle (PhA) and grip strength, and sarcopenia status was defined using the Asian Working Group for Sarcopenia criteria. Multiple linear regression models, including sex-stratified analyses, were conducted to determine the relationships of these variables with MMSE scores.
resultsHigher hemopexin levels (β = 1.19, p = 0.017), PhA (β = 0.59, p = 0.005), and grip strength (β = 0.14, p < 0.001) were independently associated with better MMSE scores, whereas sarcopenia was negatively linked to MMSE scores (β = - 2.28, p < 0.001). Notably, sex-stratified models indicated that hemopexin positively predicted MMSE scores in men but not in women; meanwhile, sarcopenia showed a stronger negative impact in women. Educational attainment also displayed a significant positive association with cognitive performance in both sexes.
conclusionsIn this cross-sectional study of older Japanese adults with cognitive impairment, hemopexin levels and muscle quality emerged as important correlates of cognitive function, particularly in men, while sarcopenia was negatively linked to cognition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.