ArticleStem cell research & therapy2025
Systemic stem cell treatment rescues injured motoneurons by reducing L-selectin expression on leukocytes.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights.Frontiers in neuroscience · 2025Pooled it
- Endoplasmic reticulum stress-mediated cell death in spinal cord injury: from molecular mechanisms to therapeutic applications.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAvulsion injury results in motoneuron death due to the increased cytotoxicity developing after the injury. We have earlier shown that intraspinally grafted immortalized NE-4C neuroectodermal stem cells derived from 9-day old mouse forebrain vesicles produced a secretome, which induced decreased microglia/macrophage reaction, and promoted the neuroprotection and regeneration following avulsion injury. Here we intended to prove the motoneuron rescuing effect of intravenously grafted NE-4C stem cells and reveal the mechanism of action used by the grafted cells.
methodsIn our experimental model the left lumbar 4 (L4) ventral root of the spinal cord was avulsed and then reimplanted into the L4 spinal segment. Treated animals received various doses of NE-4C stem cells intravenously and the survival and regeneration of the affected motoneurons was checked by morphological and functional analysis. The molecular changes within the treated cord were followed by the ELISA Proteome Profiler rat cytokine array and qPCR analysis. To mimic the effect of stem cells fucoidan treatment (a specific selectin inhibitor, 50 and 100 mg/kg bw) was applied for two weeks intraperitoneally.
resultsHigh doses of intravenous stem cell treatment (4 × 10
conclusionsBlocking L-selectin, similarly to systemic NE-4C stem cell treatment decreases the neuroinflammation in the injured spinal cord segment after ventral root avulsion and induces significant motoneuron survival and functional reinnervation of the denervated hind limb muscles.
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