Evidence map›Paper›PMID 40362279›Full record

ArticleInternational journal of molecular sciences2025

Glibenclamide Serves as a Potent Vasopressor to Treat Vasoplegia After Cardiopulmonary Bypass and Reperfusion in a Porcine Model.

Andreas Winter, Pascal Nepper, Marcus Hermann, Franziska Bayer, Stephanie Riess, Razan Salem, Jan Hlavicka, Anatol Prinzing, Florian Hecker, Tomas Holubec and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andreas WinterDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0000-0003-2818-9047
Pascal NepperDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0009-0001-4989-5998
Marcus HermannDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0000-0002-4562-1615
Franziska BayerCentral Research Unit, Goethe University Frankfurt, 60629 Frankfurt am Main, Germany.
Stephanie RiessDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.
Razan SalemDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0000-0002-9819-9382
Jan HlavickaDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0000-0003-3578-6501
Anatol PrinzingDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.
Florian HeckerDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.
Tomas HolubecDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.ORCID 0000-0003-2366-0880
Kai ZacharowskiDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.
Thomas WaltherDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.
Fabian EmrichDepartment of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University, 60629 Frankfurt am Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hemodynamic stabilization of patients after complex cardiac surgery is a daily challenge. The use of high doses of catecholamines is common but has potential adverse effects. Glibenclamide, a K

Indexed as

Cardiopulmonary BypassGlyburideVasoconstrictor AgentsVasoplegiaAnimalsBlood PressureDisease Models, AnimalHemodynamicsNorepinephrineSwineGlyburideNorepinephrineVasoconstrictor Agentscardiopulmonary bypassGlibenclamidereperfusion

Identifiers

PMID40362279
PMCPMC12071602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.