Evidence map›Paper›PMID 40362319›Full record

ArticleInternational journal of molecular sciences2025

Proteomics of Bacterial and Mouse Extracellular Vesicles Released in the Gastrointestinal Tracts of Nutrient-Stressed Animals Reveals an Interplay Between Microbial Serine Proteases and Mammalian Serine Protease Inhibitors.

Régis Stentz, Emily Jones, Lejla Gul, Dimitrios Latousakis, Aimee Parker, Arlaine Brion, Andrew J Goldson, Kathryn Gotts, Simon R Carding

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Régis StentzFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.ORCID 0000-0003-1021-9439
Emily JonesFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.ORCID 0000-0002-3040-1353
Lejla GulFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.
Dimitrios LatousakisFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.ORCID 0000-0002-2472-9328
Aimee ParkerFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.
Arlaine BrionCore Science Resources, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.
Andrew J GoldsonCore Science Resources, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.ORCID 0000-0002-7132-2459
Kathryn GottsCore Science Resources, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.
Simon R CardingFood, Microbiome and Health Research Programme, Quadram Institute Bioscience, Norwich NR4 7UQ, UK.ORCID 0000-0002-2383-9701

Funding

Biotechnology and Biological Sciences Research Council (BBSRC) BB/R012512/1
6 · The paper itself

Abstract

Bacterial extracellular vesicles (BEVs) produced by members of the intestinal microbiota can not only contribute to digestion but also mediate microbe-host cell communication via the transfer of functional biomolecules to mammalian host cells. An unresolved question is which host factors and conditions influence BEV cargo and how they impact host cell function. To address this question, we analysed and compared the proteomes of BEVs released by the major human gastrointestinal tract (GIT) symbiont

Indexed as

Bacterial ProteinsBacteroides thetaiotaomicronExtracellular VesiclesGastrointestinal TractProteomicsSerine ProteasesSerine Proteinase InhibitorsAnimalsGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLNutrientsProteomeTandem Mass SpectrometryBacterial ProteinsNutrientsProteomeSerine ProteasesSerine Proteinase Inhibitorsbacterial extracellular vesiclesBacteroides thetaiotaomicronintestinemicrobiotanutritionproteome

Identifiers

PMID40362319
PMCPMC12071298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.