Tryptophan-Derived Metabolites and Glutamate Dynamics in Fatal Insulin Poisoning: Mendelian Randomization of Human Cohorts and Experimental Validation in Rat Models.

Yuhao Yuan, Yu Liu, Shengnan Wang, Jiaxin Zhang, Xiangting Gao, Yiling Li, Zhonghao Yu, Yiwu Zhou

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Yuhao YuanDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Yu LiuDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Shengnan WangDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Jiaxin ZhangDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Xiangting GaoDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Yiling LiDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Zhonghao YuDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Yiwu ZhouDepartment of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin overdose may cause hypoglycemic encephalopathy. In this study, Mendelian randomization was employed to analyze changes in the serum metabolites of patients with hypoglycemic encephalopathy, and metabolomics analysis was conducted to detect differential metabolites in the serum of a rat model of hypoglycemic encephalopathy induced by insulin overdose. The results indicated an overall upward trend in the tryptophan metabolism pathway in patients with hypoglycemic encephalopathy and rats with hypoglycemic encephalopathy caused by insulin overdose, while serum glutamate levels declined. The metabolic changes in the tryptophan pathway provide new insights into the impact of hypoglycemia on brain function. The related products of the tryptophan metabolism pathway have a certain diagnostic value for hypoglycemic encephalopathy and forensic identification of insulin overdose-induced hypoglycemic encephalopathy death.

Indexed as

Glutamic AcidHypoglycemiaInsulinTryptophanAdultAnimalsDisease Models, AnimalFemaleHumansMaleMendelian Randomization AnalysisMetabolomicsMiddle AgedRatsRats, Sprague-DawleyGlutamic AcidInsulinTryptophanforensic identificationhypoglycemic encephalopathymendelian randomizationmetabolomicstryptophan metabolism pathway

Identifiers

PMID40362391

DOI10.3390/ijms26094152

PMCPMC12072148

What Socratic holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.