ArticleInternational journal of molecular sciences2025
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice.
Pilar Cárdenas, Catalina Cid-Salinas, Allison C León, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Rodrigo Yokota, Zoe Vallotton, Dulce Elena Casarini, Minolfa C Prieto, Ramón A Lorca and 1 more
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Pilar CárdenasInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.
Catalina Cid-SalinasInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.
Allison C LeónInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.
Juan Castillo-GeraldoInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.
Lilian Caroline Gonçalves de OliveiraDepartamento de Medicina, Disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.ORCID 0000-0001-5117-6979
Rodrigo YokotaDepartamento de Medicina, Disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
Zoe VallottonDepartment of Physiology and Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0009-0000-9776-3298
Dulce Elena CasariniDepartamento de Medicina, Disciplina de Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
Minolfa C PrietoDepartment of Physiology and Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Ramón A LorcaDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Alexis A GonzalezInstituto de Química, Pontificia Universidad Católica de Valparaíso, Valparaíso 2340000, Chile.ORCID 0000-0003-0323-1448
Funding
COVID-19 and Kidney Injury: Urinary Transcriptomics of Kidney Injury in Novel Nonhuman Primate Models of SARS-CoV-2R21AI164232 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI PRIETO, MINOLFA C · 2022 to 2023
$433k
Optogenetic and chemogenetic regulation of uterine vascular functionR21HD113796 · NICHD · UNIVERSITY OF COLORADO DENVER · PI LORCA, RAMON A · 2023 to 2023
$429k
Optogenetic control of vascular function during pregnancyR21HD102628 · NICHD · UNIVERSITY OF COLORADO DENVER · PI LORCA, RAMON A · 2021 to 2022
$428k
National Fund for Scientific and Technological Development 1220525NIAID NIH HHS R21 AI164232NICHD NIH HHS R21 HD102628NICHD NIH HHS R21 HD113796
6 · The paper itself
Abstract
Physiological control of blood pressure (BP) and extracellular fluid volume is mediated by the action of the renin-angiotensin system (RAS). The presence of RAS components throughout the nephron has been widely discussed. The (pro)renin receptor (PRR) is a member of the RAS widely expressed in the body of humans and rodents. In the kidney, PRR is expressed in mesangial cells, renal vasculature, and tubules of the proximal and distal nephron. Binding of the PRR to renin and prorenin promotes angiotensin (Ang) I-mediated sodium (Na
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
(Pro)renin Receptor Blockade Prevents Increases in Systolic Blood Pressure, Sodium Retention, and αENaC Protein Expression in the Kidney of 2K1C Goldblatt Mice. · full record | Socratic