Evidence map›Paper›PMID 40362432›Full record

ArticleInternational journal of molecular sciences2025

Role of T

Yan Liu, Yilin Yao, Yakun Yu, Ying Sun, Mingqi Wu, Rui Chen, Haoyuan Feng, Shuaitian Guo, Yanzhou Yang, Cheng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The protective role of α-lipoic acid in hypothyroidism-related ovarian damage.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan LiuCollege of Life Science, Capital Normal University, Beijing 100048, China.ORCID 0009-0002-7749-6545
Yilin YaoCollege of Life Science, Capital Normal University, Beijing 100048, China.
Yakun YuCollege of Life Science, Capital Normal University, Beijing 100048, China.
Ying SunCollege of Life Science, Capital Normal University, Beijing 100048, China.
Mingqi WuCollege of Life Science, Capital Normal University, Beijing 100048, China.
Rui ChenCollege of Life Science, Capital Normal University, Beijing 100048, China.
Haoyuan FengCollege of Life Science, Capital Normal University, Beijing 100048, China.
Shuaitian GuoCollege of Life Science, Capital Normal University, Beijing 100048, China.ORCID 0009-0009-5951-8705
Yanzhou YangKey Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan 750004, China.ORCID 0000-0002-1220-5164
Cheng ZhangCollege of Life Science, Capital Normal University, Beijing 100048, China.ORCID 0000-0003-2962-0839

Funding

National Natural Science Foundation of China 32171109
6 · The paper itself

Abstract

Thyroid hormone (TH) plays a vital role in ovarian follicle development, and glucose-regulated protein 78 (GRP78) is involved in these processes, which is regulated by TH. However, the mechanisms are still unclear. To evaluate the possible mechanism of TH on the regulation of GRP78 expression, Cleavage Under Targets and Tagmentation (CUT & Tag) sequencing, luciferase assays, and Electrophoretic Mobility Shift Assays (EMSA) were employed to delineate the binding sites of thyroid hormone receptor β (TRβ) on the GRP78 promoter and to confirm the interactions. Additionally, Co-Immunoprecipitation (Co-IP) and Immunofluorescence (IF) assays were used to investigate the interactions between TRβ and the coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) after triiodothyronine (T

Indexed as

Granulosa CellsHeat-Shock ProteinsOvaryTriiodothyronineAnimalsEndoplasmic Reticulum Chaperone BiPFemaleGene Expression RegulationPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPromoter Regions, GeneticRatsRats, Sprague-DawleyThyroid Hormone Receptors betaEndoplasmic Reticulum Chaperone BiPGRP78 protein, ratHeat-Shock ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratThyroid Hormone Receptors betaTriiodothyronineferroptosisfollicle developmentglucose-regulated protein 78granulosa cellsthyroid hormonethyroid hormone receptor

Identifiers

PMID40362432
PMCPMC12072174

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.