Evidence mapPaperPMID 40362441Full record

ArticleInternational journal of molecular sciences2025

Further Evidence of Early-Onset Osteoporosis and Bone Fractures as a New

Alice Moroni, Elena Pedrini, Morena Tremosini, Alessia Di Cecco, Dario Cocciadiferro, Antonio Novelli, Lucia Santoro, Rosanna Cordiali, Luca Sangiorgi, Maria Gnoli

Abstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alice MoroniDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-4777-341X
Elena PedriniDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0001-9980-7741
Morena TremosiniDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Alessia Di CeccoDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0009-0002-5691-0786
Dario CocciadiferroTranslational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-8583-3866
Antonio NovelliTranslational Cytogenomics Research Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-9037-4297
Lucia SantoroDepartment of Clinical Sciences, Division of Pediatrics, Azienda Ospedaliero Universitaria delle Marche, Presidio Salesi, 60126 Ancona, Italy.
Rosanna CordialiDepartment of Clinical Sciences, Division of Pediatrics, Azienda Ospedaliero Universitaria delle Marche, Presidio Salesi, 60126 Ancona, Italy.
Luca SangiorgiDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Maria GnoliDepartment of Rare Skeletal Disorders, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-5907-7470

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary osteoporosis in children and young adults often suggests a monogenic disease affecting bone microarchitecture and bone mineral density. While Osteogenesis Imperfecta (OI) is the most recognized genetic cause of recurrent fractures, many other genes involved in bone metabolism may contribute to osteoporosis. Among them, FGFR2 plays a critical role in bone growth and development by regulating osteoblast differentiation and proliferation, as well as chondrogenesis. Germline pathogenic

Indexed as

Fractures, BoneOsteoporosisReceptor, Fibroblast Growth Factor, Type 2Age of OnsetBone DensityChildExome SequencingHumansPedigreePhenotypeFGFR2 protein, humanReceptor, Fibroblast Growth Factor, Type 2early-onset osteoporosisFGFR2FGF signalingosteogenesisosteogenesis imperfectaosteoporosis

Identifiers

PMID40362441
PMCPMC12071962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.