Evidence map›Paper›PMID 40362465›Full record

ArticleInternational journal of molecular sciences2025

The 2SP Site Mutation in the Bovine Natural Resistance-Associated Macrophage 1 Promoter Exhibits Antituberculosis Potential.

Yongke Wei, Mengke Yuan, Yong Zhang, Yuanpeng Gao

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongke WeiCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Mengke YuanCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Yong ZhangCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Yuanpeng GaoCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.ORCID 0000-0002-6360-5985

Funding

National Dairy Industry Technology Innovation Center Project Topics 2022-Scientific Research Attack-3National Natural Science Foundation of China 32172706Shaanxi Provincial Key Project 2022GD-TSLD-46-0101
6 · The paper itself

Abstract

Gene-edited cattle overexpressing natural resistance-associated macrophage 1 (NRAMP1) have demonstrated enhanced resistance to tuberculosis (TB). However, introducing synthetic sequences and selection markers may pose potential risks. The endogenous editing of target gene promoters could effectively mitigate these risks. To date, no available mutation sites in the bovine

Indexed as

Cation Transport ProteinsMutationPromoter Regions, GeneticTuberculosisAnimalsCattleGene EditingHumansMycobacterium tuberculosisNatural Resistance-associated Macrophage Protein 1THP-1 CellsTuberculosis, BovineCation Transport ProteinsNatural Resistance-associated Macrophage Protein 1base editingNRAMP1promoter analysistuberculosis

Identifiers

PMID40362465
PMCPMC12071736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.