Evidence map›Paper›PMID 40362541›Full record

ArticleInternational journal of molecular sciences2025

Comparative Evaluation of Platelet-Rich Fibrin (PRF) and Concentrated Growth Factor (CGF) as Carriers for Antibiotics-In Vitro Study.

Wojciech Niemczyk, Małgorzata Kępa, Jacek Żurek, Ali Aboud, Dariusz Skaba, Rafał Wiench

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wojciech NiemczykDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Pl. Traugutta 2, 41-800 Zabrze, Poland.ORCID 0000-0003-0172-0571
Małgorzata KępaDepartment of Microbiology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0002-4013-6688
Jacek ŻurekSpecialist Medical Practice-Clinical Periodontology, Żuradzka 15 Street, 32-300 Olkusz, Poland.
Ali AboudMedical Center of Innovation, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.ORCID 0009-0004-8485-9302
Dariusz SkabaDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Pl. Traugutta 2, 41-800 Zabrze, Poland.ORCID 0000-0001-8732-251X
Rafał WienchDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Pl. Traugutta 2, 41-800 Zabrze, Poland.ORCID 0000-0001-5673-7413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factors (LPCGFs), have emerged as potential carriers for antimicrobial agents. This study aimed to evaluate the efficacy of c-PRF and LPCGF as carriers for three antibiotic formulations-amoxicillin with clavulanic acid, clindamycin, and a combination of amoxicillin with metronidazole-against methicillin-sensitive

Indexed as

Anti-Bacterial AgentsDrug CarriersIntercellular Signaling Peptides and ProteinsPlatelet-Rich FibrinAmoxicillinClindamycinEnterococcus faecalisHumansMethicillin-Resistant Staphylococcus aureusMetronidazoleMicrobial Sensitivity TestsAmoxicillinAnti-Bacterial AgentsClindamycinDrug CarriersIntercellular Signaling Peptides and ProteinsMetronidazoleantibioticsbacteriablooddrug resistancegrowth factorsin vitroplatelet-rich fibrinplatelets

Identifiers

PMID40362541
PMCPMC12072872

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.