Evidence map›Paper›PMID 40362576›Full record

ArticleInternational journal of molecular sciences2025

Silencing

Amelia Meecham, Sara McCurdy, Eduardo Frias-Anaya, Wenqing Li, Helios Gallego-Gutierrez, Phu Nguyen, Yi-Shuan Li, Shu Chien, John Y-J Shyy, Mark H Ginsberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Amelia MeechamDepartment of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0003-3067-7621
Sara McCurdyDepartment of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0001-7854-8808
Eduardo Frias-AnayaDepartment of Medicine, University of California, La Jolla, CA 92093, USA.
Wenqing LiDepartment of Medicine, University of California, La Jolla, CA 92093, USA.
Helios Gallego-GutierrezDepartment of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0003-0369-9083
Phu NguyenDepartment of Bioengineering, University of California, La Jolla, CA 92093, USA.
Yi-Shuan LiDepartment of Bioengineering, University of California, La Jolla, CA 92093, USA.
Shu ChienDepartment of Bioengineering, University of California, La Jolla, CA 92093, USA.
John Y-J ShyyDepartment of Bioengineering, University of California, La Jolla, CA 92093, USA.
Mark H GinsbergDepartment of Medicine, University of California, La Jolla, CA 92093, USA.
Miguel Alejandro Lopez-RamirezDepartment of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0001-7089-4060

Funding

The Hemostasis, Thrombosis, and Inflammation Models CoreP01HL151433 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark HOWARD Ginsberg · 2020 to 2026
$16.4M
Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in AtherosclerosisR01HL162367 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2022 to 2025
$3.0M
AMPK Regulation of ACE2 in Endothelial Health and DiseaseR01HL162302 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHYY, JOHN YJ, ZHANG, JIN · 2022 to 2025
$2.7M
Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A ModificationR01HL170107 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHU CHIEN, John YJ Shyy · 2024 to 2026
$2.5M
Mechanisms of hypoxia induced exacerbation of cerebral cavernous malformationsR01NS121070 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Miguel Alejandro Lopez-Ramirez · 2022 to 2026
$2.3M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NHLBI NIH HHS P01 HL151433NHLBI NIH HHS R01 HL121365NHLBI NIH HHS R01 HL162302NHLBI NIH HHS R01 HL162367NHLBI NIH HHS R01 HL170107NIH HHS R01NS121070NIH HHS S10 OD026929NINDS NIH HHS R01 NS121070
6 · The paper itself

Abstract

Endothelial cells respond to forces generated by laminar blood flow with changes in vasodilation, anticoagulant, fibrinolytic, or anti-inflammatory functions which preserve vessel patency. These responses to flow shear stress are primarily mediated by the modulation of the following transcription factors: Krüppel-like factors 2 and 4 (KLF2 and KLF4). Notably, disturbed flow patterns, which are found in vascular areas predisposed to atherosclerosis, significantly reduce the endothelial expression of KLF2 and KLF4, resulting in changes in the transcriptome that exacerbate inflammation and thrombosis. The endothelial CCM (Cerebral Cavernous Malformation) complex, comprising KRIT1 (Krev1 interaction trapped gene 1), CCM2 (Malcavernin), and CCM3 (Programmed cell death protein 10), suppresses the expression of KLF2 and KLF4. Loss of function of the CCM complex has recently been suggested to protect from coronary atherosclerosis in humans. We thus hypothesized that the silencing of

Indexed as

Endothelial CellsKRIT1 ProteinTranscriptomeAtherosclerosisGene SilencingHumansHuman Umbilical Vein Endothelial CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsStress, MechanicalKLF2 protein, humanKLF4 protein, humanKRIT1 ProteinKRIT1 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription Factorsatherosclerosisendothelial cellsendotheliumoscillatory shear stresspulsatile shear stressvasoprotection

Identifiers

PMID40362576
PMCPMC12072803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.