Evidence map›Paper›PMID 40362615›Full record

ArticleInternational journal of molecular sciences2025

Genome Announcement of Four Parechovirus A3 Isolates from the United States of America.

Debarpan Dhar, Terry Fei Fan Ng, Christopher J Harrison, Eric Rhoden, Bernardo A Mainou, Anjana Sasidharan, Katelyn E VanDonge, Varun Chandra Boinpelly, Rangaraj Selvarangan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Debarpan DharDepartment of Pathology and Laboratory Medicine, Emerging Infections, Children's Mercy Research Institute, Kansas City, MO 64108, USA.ORCID 0000-0002-6776-5089
Terry Fei Fan NgDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0002-4815-8697
Christopher J HarrisonSchool of Medicine, University of Missouri, Kansas City, MO 64108, USA.ORCID 0000-0003-4281-1824
Eric RhodenDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0001-8642-9948
Bernardo A MainouDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.ORCID 0000-0002-7721-183X
Anjana SasidharanDepartment of Pathology and Laboratory Medicine, Emerging Infections, Children's Mercy Research Institute, Kansas City, MO 64108, USA.ORCID 0009-0008-7559-1796
Katelyn E VanDongeDepartment of Pathology and Laboratory Medicine, Emerging Infections, Children's Mercy Research Institute, Kansas City, MO 64108, USA.
Varun Chandra BoinpellyDepartment of Pathology and Laboratory Medicine, Emerging Infections, Children's Mercy Research Institute, Kansas City, MO 64108, USA.
Rangaraj SelvaranganDepartment of Pathology and Laboratory Medicine, Emerging Infections, Children's Mercy Research Institute, Kansas City, MO 64108, USA.ORCID 0000-0003-3275-6657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the complete genome sequences of four parechovirus-A3 (PeV-A3) isolates from Children's Mercy Kansas City (CMKC), United States of America (USA): PeV-A3-MO-12-CMKC/CSF/MO/USA/2012 (isolated in 2012 from cerebrospinal fluid), PeV-A3-8C-CMKC/CSF/MO/USA/2022/ (isolated in 2022 from cerebrospinal fluid), PeV-A3-9C-CMKC/CSF/MO/USA/2022 (isolated in 2022 from cerebrospinal fluid), and PeV-A3-11B-CMKC/Blood/MO/USA/2022 (isolated in 2022 from blood). Sequence analysis revealed multiple mutations throughout the genome of the PeV-A3 isolates in comparison to the prototypic PeV-A3 A308/99 reference sequence (AB084913). Several unique amino acid changes were observed in the PeV-A3 isolates from 2022 that were absent in the PeV-A3 isolate from 2012. Phylogenetic analysis comparison determined that the sequenced PeV-A3 isolates from 2022 cluster together as a separate clade.

Indexed as

Genome, ViralParechovirusPicornaviridae InfectionsHumansPhylogenyUnited StatesWhole Genome SequencingmutationsPeV-A3phylogenywhole genome sequencing

Identifiers

PMID40362615
PMCPMC12072549

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.