Evidence map›Paper›PMID 40362685›Full record

ReviewInternational journal of molecular sciences2025

Altering the Hydrogen Isotopic Composition of the Essential Nutrient Water as a Promising Tool for Therapy: Perspectives and Risks.

Nataliya V Yaglova, Sergey S Obernikhin, Ekaterina P Timokhina, Elina S Tsomartova, Valentin V Yaglov, Svetlana V Nazimova, Marina Y Ivanova, Elizaveta V Chereshneva, Tatiana A Lomanovskaya, Dibakhan A Tsomartova

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nataliya V YaglovaLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.ORCID 0000-0002-8239-5039
Sergey S ObernikhinLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.ORCID 0000-0003-0997-6766
Ekaterina P TimokhinaLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.ORCID 0000-0003-0504-1488
Elina S TsomartovaLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.
Valentin V YaglovLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.
Svetlana V NazimovaLaboratory of Endocrine System Development, A.P. Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", 119991 Moscow, Russia.
Marina Y IvanovaDepartment of Human Anatomy and Histology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Elizaveta V ChereshnevaDepartment of Human Anatomy and Histology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.ORCID 0000-0002-1046-6336
Tatiana A LomanovskayaDepartment of Human Anatomy and Histology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.
Dibakhan A TsomartovaDepartment of Human Anatomy and Histology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water is a vital nutrient that is needed to maintain almost all biological processes in living organisms. The natural water contains two isotopes of hydrogen-protium and deuterium. Deuterium, the trace component of natural water, significantly changes its physical and chemical properties and biological action. In this review, the authors summarize data on the isotopic effects of deuterium and discuss the possible magnetic effects of isotopes and the molecular basis of the biological effects of deuterium-depleted water. The review also presents new data on the already known and potential use of deuterium-depleted water in medicine (oncology, neurology) and previously unknown new directions of its use (immunological and endocrine disorders, anemia). Based on the analysis of collected data, the authors presented mechanisms of action of deuterium-depleted water in the organism. The authors also identified the least-studied effects of deuterium-depleted water, particularly its influence on morphogenetic processes. The review discloses the perspectives on deuterium-depleted water as a tool for therapy and substantiates the risks of its uncontrolled intake.

Indexed as

DeuteriumNutrientsWaterAnimalsHumansHydrogenDeuteriumHydrogenNutrientsWateranemiadeuterium-depleted waterendocrinologyhydrogenimmunologyisotope effectneurologyoncologywater

Identifiers

PMID40362685
PMCPMC12072384

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.