Evidence map›Paper›PMID 40362693›Full record

ArticleInternational journal of molecular sciences2025

Genetic Modifiers Associated with Vaso-Occlusive Crises and Acute Pain Phenomena in Sickle Cell Disease: A Scoping Review.

Froso Sophocleous, Natasha M Archer, Carsten W Lederer, International Hemoglobinopathy Research Network (INHERENT)

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Genetics and Genomics in Sickle Cell Disease in Africa.American journal of hematology · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Froso SophocleousMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.
Natasha M ArcherPediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA 02115, USA.
Carsten W LedererMolecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology & Genetics, 6 Iroon Avenue, Ayios Dometios, Nicosia 2371, Cyprus.ORCID 0000-0003-3920-9584
International Hemoglobinopathy Research Network (INHERENT)

Funding

European Cooperation in Science and Technology CA22119
6 · The paper itself

Abstract

Sickle cell disease (SCD) is a group of recessive diseases caused by the β

Indexed as

Acute PainAnemia, Sickle CellVascular DiseasesFemaleGenetic Predisposition to DiseaseHumansMaleVaso-Occlusive Crisesacute chest syndromeavascular necrosisdactylitisgenetic disease modifierGWAShemoglobinopathypriapismsickle cell diseasesplenic sequestrationvaso-occlusive crises

Identifiers

PMID40362693
PMCPMC12072568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.