Evidence map›Paper›PMID 40362822›Full record

ArticleNutrients2025

NSAIDs, Ileal Inflammation, and Glucose Metabolism: Insights from a Large Retrospective Cohort.

Stephanie Hosanna Rodriguez, Gilles Jadd Hoilat, Nikash Pradhan, Carolina Gonzalez Bravo, Marcelo L G Correia, Mohamad Mokadem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie Hosanna RodriguezDepartment of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0005-5962-885X
Gilles Jadd HoilatDepartment of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Nikash PradhanDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52246, USA.
Carolina Gonzalez BravoDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52246, USA.
Marcelo L G CorreiaDepartment of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-3470-6234
Mohamad MokademDepartment of Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1402-580X

Funding

BLRD VA I01 BX004774United States Department of Veterans Affairs 2 I01 BX004774-05
6 · The paper itself

Abstract

BACKGROUND/

objectivesIleitis, or inflammation of the terminal ileum, is often linked to inflammatory bowel disease (IBD), especially Crohn's disease, but may also arise from non-steroidal anti-inflammatory drug (NSAID) use. While NSAIDs are known to cause gastrointestinal injury, their role in ileitis and downstream metabolic consequences remains unclear. This study evaluated the relationship between NSAID use, biopsy-confirmed ileitis, and glucose metabolism abnormalities in patients with and without IBD.

methodsWe conducted a retrospective cohort study of 3725 adults who underwent ileal biopsy between 2009 and 2022 at a tertiary care center. Patients were stratified based on histologic evidence of ileitis. Collected data included demographics, IBD status, NSAID and steroid use, hemoglobin A1C, fasting glucose, and diagnoses of abnormal glucose metabolism. Multivariable logistic and linear regression models adjusted for age, BMI, sex, steroid use, and IBD.

resultsOf 3725 patients, 876 had biopsy-confirmed ileitis. NSAID use-categorized as current, historical, or inpatient-was not significantly associated with ileitis after adjustment. In contrast, IBD was the strongest independent predictor (

conclusionsNSAID use was not associated with biopsy-confirmed ileitis or impaired glucose metabolism. Traditional metabolic risk factors were stronger predictors of glycemic abnormalities than localized ileal inflammation.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalBlood GlucoseGlucoseIleitisAdultAgedBiopsyFemaleGlycated HemoglobinHumansIleumInflammationInflammatory Bowel DiseasesMaleMiddle AgedRetrospective StudiesAnti-Inflammatory Agents, Non-SteroidalBlood GlucoseGlucoseGlycated Hemoglobinileitisinflammatory bowel disease (IBD)non-steroidal anti-inflammatory drugs (NSAIDs)type 2 diabetes mellitus (T2DM)

Identifiers

PMID40362822
PMCPMC12073212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.