ArticleNutrients2025
Temporal Trends and Clinical Impact of Malnutrition on In-Hospital Outcomes Among Patients with Advanced Chronic Kidney Disease: A Nationwide Inpatient Analysis.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nutritional Challenges in Hemodialysis: A Perspective from Albania.The Eurasian journal of medicine · 2026Article
- Decline and Resurgence of Cardiovascular-Kidney-Metabolic Syndrome-Related Deaths Involving Malnutrition in the United States, 1999 to 2023.Journal of the American Heart Association · 2026Article
- Association of malnutrition with in-hospital outcomes among patients hospitalized with dermatomyositis or polymyositis.Clinical rheumatology · 2026Article
- Systematic Review of Exercise Training and Musculoskeletal Health in Patients Receiving Dialysis.Kidney international reports · 2026Article
- Nephrology Nurses' Nutritional Competence in Chronic Kidney Disease Care: A Qualitative Study.Nursing reports (Pavia, Italy) · 2026Article
- Article
- Competency of Nurses in Providing Dietary Guidance to Patients with Chronic Kidney Disease in Anhui Province: Influencing Factors.Journal of multidisciplinary healthcare · 2026Article
- Racial disparities in in-hospital outcomes and costs among U.S. patients on peritoneal dialysis: a 15-year national cohort study.Scientific reports · 2025Article
- Outcomes of Hospitalized Liver Cirrhosis Patients With COVID-19 Infection: A Retrospective Analysis.Cureus · 2025Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesMalnutrition is a prevalent yet under-recognized condition in patients with advanced chronic kidney disease (CKD), contributing to increased morbidity, mortality, and healthcare burden. The aim of this study is to determine the prevalence and trends of malnutrition and investigate the impact of malnutrition on in-hospital outcomes, treatments, and resource utilization in hospitalized patients with advanced CKD.
methodsThis study utilized the National Inpatient Sample (NIS) database to identify hospitalized patients with advanced CKD from 2016 to 2021. This study investigated temporal trends in the prevalence and in-hospital mortality across different degrees of malnutrition in advanced CKD patients. Multivariable regression models were used to assess the association between malnutrition and in-hospital outcomes.
resultsOut of 1,244,415 advanced CKD patients, 67,587 (5.4%) had mild to moderate malnutrition, and 63,785 (5.1%) had severe malnutrition. Malnourished patients exhibited significantly higher in-hospital mortality, with adjusted odds ratios of 1.70 (95% confidence interval (CI), 1.64-1.75) for mild to moderate cases and 2.67 (95% CI, 2.60-2.75) for severe cases. Severely malnourished patients were associated with longer mean hospital stay by 7.0 days and higher hospitalization costs by $97,767 compared with non-malnourished patients. The prevalence of severe malnutrition showed a significant uptrend from 4.2% in 2016 to 5.5% in 2021 (
conclusionsMalnutrition in advanced CKD is an increasingly prevalent condition linked to worsened in-hospital outcomes and heightened healthcare resource utilization. The rising trend of severe malnutrition underscores the need for early nutritional screening and the need for future interventional studies to mitigate adverse clinical outcomes in this high-risk population.
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