Evidence map›Paper›PMID 40362907›Full record

ArticleNutrients2025

Specific Bacterial Taxa and Their Metabolite, DHPS, May Be Linked to Gut Dyshomeostasis in Patients with Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.

Courtney Jayde Christopher, Katherine Hope Morgan, Christopher Mahone Tolleson, Randall Trudell, Roberto Fernandez-Romero, Lexis Rice, Blessing A Abiodun, Zane Vickery, Katarina A Jones, Brittni Morgan Woodall and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Courtney Jayde ChristopherDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0002-8387-4779
Katherine Hope MorganCollege of Nursing, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0003-3673-5570
Christopher Mahone TollesonThe Cole Center for Parkinson's and Movement Disorders, The University of Tennessee Medical Center, Knoxville, TN 37922, USA.
Randall TrudellThe Cole Center for Parkinson's and Movement Disorders, The University of Tennessee Medical Center, Knoxville, TN 37922, USA.
Roberto Fernandez-RomeroThe Pat Summitt Clinic, The University of Tennessee Medical Center, Knoxville, TN 37920, USA.
Lexis RiceDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
Blessing A AbiodunDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0009-0009-3370-6468
Zane VickeryDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.
Katarina A JonesBiological and Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0003-3769-8599
Brittni Morgan WoodallDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.
Christopher NagyHigh Throughput Sequencing Facility, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0003-3628-9360
Piotr Andrzej MieczkowskiDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0003-2418-0096
Gregory BowenIntegrated Genomics Cores, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Shawn R CampagnaDepartment of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0001-6809-3862
Joseph Christopher EllisNetEllis, LLC, Knoxville, TN 37934, USA.

Funding

A philanthropic donor to ALS research at the University of Tennessee Medical Center N/ALaboratory Directed Research and Development Program at Oak Ridge National Laboratory, managed by UT-Battelle, LLC, for the U.S. Department of Energy N/AThe Cole Family who support Parkinson's care and research at the Cole Center for Parkinson's Disease and Movement Disorders N/AUniversity of Tennessee at Knoxville's Human Health & Wellness Program N/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyotrophic Lateral SclerosisBacteriaDysbiosisGastrointestinal MicrobiomeParkinson DiseaseAgedCase-Control StudiesFecesFemaleHomeostasisHumansMaleMetabolomicsMiddle Aged2,3-dihydroxypropane-1-sulfonate (DHPS)Alzheimer’s diseaseamyotrophic lateral sclerosisbacterial-derivedmetabolomicsmicrobiomeneurodegenerative diseaseParkinson’s disease

Identifiers

PMID40362907
PMCPMC12073124

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.