ArticlePolymers2025
Sago-Starch-Derived Sodium Starch Glycolate: An Effective Superdisintegrant to Enhance Formulation Performance.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Recent Advances and Future Perspectives on Chitosan-Sago-Derived Sodium Starch Glycolate as a Biopolymeric Carrier for Alpha-Mangostin Nanoparticles in Wound Healing.International journal of nanomedicine · 2026Review
- The Potential of α-Mangostin-Loaded Chitosan/Collagen Nanoparticles in Hydrogel Formulation for Enhanced Wound Healing.Nanotechnology, science and applications · 2026Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This study focused on optimizing sago-starch-derived sodium starch glycolate (SSG) as a superdisintegrant using a Response Surface Methodology (RSM). The aim was to enhance the formulation performance by achieving an optimal degree of substitution (DS) in the synthesis of SSG from sago starch and evaluating its performance in mefenamic acid tablet formulation. The SSG was synthesized using an organic solvent slurry method, which involves crosslinking starch with sodium trimetaphosphate (STMP) and substituting it with sodium monochloroacetate (SMCA). The reaction conditions, including the temperature, SMCA ratio, and reaction time, were optimized using the RSM. The optimal conditions were identified as a temperature range of 45-55 °C, an SMCA ratio of 0.75-1.5, and a reaction time of 120-240 min. The maximum predicted DS value was 0.24, with a validated DS value of 0.246 ± 0.021. The SSG-containing mefenamic acid formulation met USP standards and showed a superior disintegration time compared to the existing SSG. The optimized SSG derived from sago starch can be effectively used as a superdisintegrant in pharmaceutical formulations, offering a sustainable and economically viable alternative source of SSG. This contributes to the development of more effective drug delivery systems and promotes sustainable agriculture in Indonesia.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.