Evidence map›Paper›PMID 40363689›Full record

ArticleMolecules (Basel, Switzerland)2025

An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream.

Dessislava Lazarova, Plamen Getsov, Rumiana Bakalova, Biliana Nikolova, Severina Semkova, Zhivko Zhelev, Zhiwei Qiao, Tomohiro Ishikawa, Koichiro Fukuda, Kensuke Osada and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dessislava LazarovaFaculty of Medicine, Sofia University "St. Kliment Ohridski", 1407 Sofia, Bulgaria.
Plamen GetsovFaculty of Medicine, Medical University, 1000 Sofia, Bulgaria.
Rumiana BakalovaFaculty of Medicine, Sofia University "St. Kliment Ohridski", 1407 Sofia, Bulgaria.
Biliana NikolovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-9742-9812
Severina SemkovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Zhivko ZhelevInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Zhiwei QiaoLTT Bio-Pharma Co., Ltd., Tokyo 105-0013, Japan.ORCID 0009-0008-5380-0219
Tomohiro IshikawaLTT Bio-Pharma Co., Ltd., Tokyo 105-0013, Japan.ORCID 0000-0002-0539-7372
Koichiro FukudaLTT Bio-Pharma Co., Ltd., Tokyo 105-0013, Japan.
Kensuke OsadaInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.ORCID 0000-0001-9557-6851
Milka MilevaStephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-3218-4487
Tohru MizushimaLTT Bio-Pharma Co., Ltd., Tokyo 105-0013, Japan.
Ichio AokiInstitute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.

Funding

The European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria SUMMIT BG-RRP-2.004-0008-C01
6 · The paper itself

Abstract

Lecithinized superoxide dismutase (PC-SOD) was found to have a significantly improved half-life in the bloodstream and better pharmacological effects compared with unmodified SOD. However, there is no direct evidence that parenterally administered PC-SOD decreases superoxide levels in blood and tissues in vivo. In the present study, we investigated the ability of PC-SOD versus unmodified SOD as a superoxide scavenger in mice subjected to oxidative stress. Experiments were performed on a lipopolysaccharide (LPS) mouse model of acute inflammation known to be accompanied by the overproduction of superoxide in the blood. The mice were divided into four groups: untreated (healthy;

Indexed as

Free Radical ScavengersPhosphatidylcholinesSuperoxide DismutaseSuperoxidesAnimalsElectron Spin Resonance SpectroscopyLipopolysaccharidesMaleMiceOxidation-ReductionOxidative StressFree Radical Scavengerslecithinized superoxide dismutaseLipopolysaccharidesPhosphatidylcholinesSuperoxide DismutaseSuperoxidesEPR spectroscopyinflammationlecithinized superoxide dismutaseoxidative stressredox state

Identifiers

PMID40363689
PMCPMC12073531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.