Design, Synthesis, and Biological Evaluation of Naphthoquinone Salts as Anticancer Agents.

Yao Cheng, Tsz Tin Yu, Ellen M Olzomer, Kyle L Hoehn, Frances L Byrne, Naresh Kumar, David StC Black

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao ChengSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0009-0006-7697-5412

Tsz Tin YuSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-8484-7342

Ellen M OlzomerSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-5823-0736

Kyle L HoehnSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0214-3238

Frances L ByrneSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-8897-8438

Naresh KumarSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-0951-9621

David StC BlackSchool of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-9300-4737

Funding

Cancer Institute NSW fellowships Early Career 2018/ECF003Career Development 2021/CDF1120)

6 · The paper itself

Abstract

The Warburg effect, a unique glycolytic phenomenon in cancer cells, presents a promising target for developing selective anticancer agents. Previously,

Indexed as

Antineoplastic AgentsDrug DesignNaphthoquinonesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansKelch-Like ECH-Associated Protein 1Molecular Docking SimulationMolecular StructureSaltsStructure-Activity RelationshipAntineoplastic AgentsKEAP1 protein, humanKelch-Like ECH-Associated Protein 1NaphthoquinonesSaltsanticancerglycolysisnaphthoimidazoleselectivity

Identifiers

PMID40363746

DOI10.3390/molecules30091938

PMCPMC12073298

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.