Polygenic Risk Score Is Associated with Developing and Dying from Lung Cancer in the National Lung Screening Trial.

Robert P Young, Raewyn J Scott, Tom Callender, Fenghai Duan, Paul Billings, Denise R Aberle, Greg D Gamble

Abstract read

In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Polygenic risk scores in cancer.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
Article
Harnessing genomics for early cancer detection, risk stratification and prevention.Nature genetics · 2026
Review
Gene-based lung cancer detection system through omix data and optimized convolutional neural network.Journal of computer-aided molecular design · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert P YoungFaculty of Medical and Health Sciences, University of Auckland, Auckland P.O. Box 37-971, New Zealand.

Raewyn J ScottFaculty of Medical and Health Sciences, University of Auckland, Auckland P.O. Box 37-971, New Zealand.

Tom CallenderDepartment of Applied Health Research, University College London, London WC1E6B1, UK.

Fenghai DuanDepartment of Biostatistics and Centre for Biostatistics and Health Data Science, Brown University of Public Health, Providence, RI 02912, USA.

Paul BillingsNatera Inc., Austin, TX 78753, USA.

Denise R AberleDepartment of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

Greg D GambleFaculty of Medical and Health Sciences, University of Auckland, Auckland P.O. Box 37-971, New Zealand.ORCID 0000-0003-0412-3203

Funding

This study was funded by a grant from Johnson and Johnson (no grant number), and grants U01-CA-80098 and U01-CA-79778 to the American College of Radiology Imaging Network (ACRIN). U01-CA-80098 and U01-CA-79778

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

lung canceroutcomespolygenic risk scorescreening

Identifiers

PMID40364136

DOI10.3390/jcm14093110

PMCPMC12073000

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.