Evidence map›Paper›PMID 40364191›Full record

ReviewJournal of clinical medicine2025

Traumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management.

Ben Teasdale, Edwin Owolo, Varun Padmanaban, Aladine A Elsamadicy, Abdelaziz Amllay, Ganesh M Shankar, Penina P Krieger, Robert W Regenhardt, Ryan M Hebert, Christopher J Stapleton and 4 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ben TeasdaleDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0001-9904-3518
Edwin OwoloDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Varun PadmanabanDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9538-7708
Aladine A ElsamadicyDepartment of Neurosurgery, Yale-New Haven Hospital, Yale University, New Haven, CT 06510, USA.
Abdelaziz AmllayDepartment of Neurosurgery, Yale-New Haven Hospital, Yale University, New Haven, CT 06510, USA.ORCID 0000-0003-3357-4134
Ganesh M ShankarDepartment of Neurosurgery, Yale-New Haven Hospital, Yale University, New Haven, CT 06510, USA.
Penina P KriegerDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID 0009-0001-5351-5628
Robert W RegenhardtDepartment of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0000-0003-2958-3484
Ryan M HebertDepartment of Neurosurgery, Yale-New Haven Hospital, Yale University, New Haven, CT 06510, USA.
Christopher J StapletonDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
James D RabinovDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Charles C MatoukDepartment of Neurosurgery, Yale-New Haven Hospital, Yale University, New Haven, CT 06510, USA.
Aman B PatelDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.
Nanthiya SujijantaratDepartment of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-5857-5718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vertebral artery injury (VAI) is a known complication of blunt cervical spine trauma with a potential risk of stroke. Factors including cervical bony injury, spinal cord injury, and overall trauma severity have been linked to an increased risk of VAI. Despite its prevalence, there is little consensus on various aspects of this pathology, including its initial screening, diagnostic approaches, and therapeutic strategies. A recent systematic review and meta-analysis from our group highlighted the dynamic nature of vertebral artery occlusion, revealing the underrecognized recanalization rates and potential stroke risks associated with delayed recanalization. While anticoagulant and/or antiplatelet therapy (ACAP) remains the cornerstone of VAI management, treatment is often complicated by co-existing injuries, such as intracranial hemorrhage or cervical trauma, which may preclude or delay ACAP usage or necessitate surgical intervention. This comprehensive narrative review synthesizes the latest evidence on VAI and associated ischemic sequelae, with the goal of elucidating its pathophysiology and natural history, summarizing current data on screening and diagnosis, and exploring key considerations for medical and endovascular management.

Indexed as

blunt cerebrovascular injurycervical traumaspinal injurytraumatic vertebral occlusionvertebral artery injury

Identifiers

PMID40364191
PMCPMC12072270

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.