Evidence map›Paper›PMID 40365161›Full record

ArticlePNAS nexus2025

5G-exposed human skin cells do not respond with altered gene expression and methylation profiles.

Jyoti Jyoti, Isabel Gronau, Eda Cakir, Marc-Thorsten Hütt, Alexander Lerchl, Vivian Meyer

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jyoti JyotiSchool of Science, Constructor University, Bremen 28759, Germany.ORCID https://orcid.org/0000-0001-6654-7971
Isabel GronauSchool of Science, Constructor University, Bremen 28759, Germany.
Eda CakirSchool of Science, Constructor University, Bremen 28759, Germany.ORCID https://orcid.org/0000-0001-5337-3095
Marc-Thorsten HüttSchool of Science, Constructor University, Bremen 28759, Germany.
Alexander LerchlSchool of Science, Constructor University, Bremen 28759, Germany.ORCID https://orcid.org/0000-0002-4589-7814
Vivian MeyerSchool of Science, Constructor University, Bremen 28759, Germany.ORCID https://orcid.org/0000-0002-7694-8573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the ever-increasing wirelessly transmitted data, the development of new transmission standards and higher frequencies in the 5G band is required. Despite basic biophysical considerations that argue against health effects, there is public concern about this technology. Because the skin penetration depth at these frequencies is only 1 mm or less, we exposed fibroblasts and keratinocytes to electromagnetic fields up to ten times the permissible limits, for 2 and 48 h in a fully blinded experimental design. Sham-exposed cells served as negative, and UV-exposed cells as positive controls. Differences in gene expression and methylation due to exposure were small and not higher than expected by chance. These data strongly support the assessment that there is no evidence for exposure-induced damage to human skin cells.

Indexed as

5G radiofrequencyelectromagnetic fieldsin vitrosystems biology

Identifiers

PMID40365161
PMCPMC12070386

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.