Evidence map›Paper›PMID 40365860›Full record

ArticleThe Cochrane database of systematic reviews2025

Total neoadjuvant therapy for locally advanced rectal cancer.

Sophie Mueller, Yung-Shuo Kao, Carolin Kastner, Po-Huang Chen, Anne Hendricks, Gin Yi Lee, Franziska Koehler, Hong-Jie Jhou, Christoph-Thomas Germer, Enoch Yi-No Kang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cochrane database of systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sophie MuellerDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Yung-Shuo KaoDepartment of Radiation Oncology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
Carolin KastnerDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Po-Huang ChenDepartment of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Anne HendricksDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Gin Yi LeeDepartment of Medicine, Brigham and Women's Hospital, Boston, USA.
Franziska KoehlerDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Hong-Jie JhouDepartment of Neurology, Changhua Christian Hospital, Changhua, Taiwan.
Christoph-Thomas GermerDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Enoch Yi-No KangEvidence-Based Medicine Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Heidrun JankaInstitute of General Practice, Medical Faculty of the Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ching-Liang HoDivision of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Cho-Hao LeeDivision of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Armin WiegeringDepartment of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of total neoadjuvant therapy versus standard therapy in individuals with locally advanced rectal cancer.

Indexed as

Neoadjuvant TherapyRectal NeoplasmsHumansMeta-Analysis as TopicRandomized Controlled Trials as TopicSystematic Reviews as Topic

Identifiers

PMID40365860
PMCPMC12076550

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.