Evidence map›Paper›PMID 40366401›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Toxicological and anti-inflammatory activities of doxorubicin loaded onto pH-sensitive poly(β-amino ester) modified mesoporous silica nanoparticles in mice.

Alejandro Ávila-Ortega, Fabiola Elizabeth Villa-de la Torre, Cristian Carrera-Figueiras, Abril Bernardette Martínez-Rizo, William Alejandro Talavera-Pech, Julio César Torres-Romero, Emanuel Ceballos-Góngora, Valeria García-Martínez, Valeria Guadalupe Pintor-Romero, Claribel Huchin-Chan and 2 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alejandro Ávila-OrtegaCuerpo Académico de Química Fundamental y Aplicada, Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.ORCID http://orcid.org/0000-0002-9719-5996
Fabiola Elizabeth Villa-de la TorreLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México.ORCID http://orcid.org/0009-0001-0663-3154
Cristian Carrera-FigueirasCuerpo Académico de Química Fundamental y Aplicada, Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.ORCID http://orcid.org/0000-0001-8208-5922
Abril Bernardette Martínez-RizoLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México.ORCID http://orcid.org/0000-0002-8381-3730
William Alejandro Talavera-PechCentro de Investigación en Corrosión, Universidad Autónoma de Campeche, Av. Héroe de Nacozari No. 480, San Francisco de Campeche, Campeche, 24079, México.ORCID http://orcid.org/0000-0002-3260-3020
Julio César Torres-RomeroLaboratorio de Bioquímica y Genética Molecular, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.ORCID http://orcid.org/0000-0002-0417-0969
Emanuel Ceballos-GóngoraLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México.ORCID http://orcid.org/0000-0002-6015-3223
Valeria García-MartínezLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México.ORCID http://orcid.org/0009-0002-2314-2688
Valeria Guadalupe Pintor-RomeroLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México.ORCID http://orcid.org/0009-0000-4812-2937
Claribel Huchin-ChanLaboratorio de Análisis Clínicos y de Servicio a La Comunidad, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.ORCID http://orcid.org/0009-0002-6750-1291
Alfredo Rafael Vilchis-NestorCentro Conjunto de Investigación en Química Sustentable, UAEM-UNAM, Toluca, México.ORCID http://orcid.org/0000-0001-8490-0900
Víctor Ermilo Arana-ArgáezLaboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Calle 43, No 613 X Calle 90, Col. Inalámbrica, CP. 97069, Mérida, Yucatán, México. victor.arana@correo.uady.mx.ORCID http://orcid.org/0000-0003-1434-1677

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy drugs used in inflammatory disorders and some cancers, while effective, often cause diverse side toxic effects, prompting research into alternatives to ameliorate damage in healthy tissues. One strategy is to encapsulate doxorubicin (DOX) chemotherapeutic agents into nano-vehicles, such as organic-functionalized mesoporous nanoparticles, to reduce systemic leakage and adverse effects, such as inflammation. This study analyzes the toxicological and anti-inflammatory effects of a drug-delivered system (DDS) based on MCM-41 mesoporous silica nanoparticles modified with a pH-sensitive poly(β-amino ester) named MCM-41-PbAE. The effects of both blank nanoparticles (MCM-41-PbAE) and those with encapsulated DOX (MCM-41-PbAE-DOX) were evaluated in LPS-stimulated mouse macrophages and in an in vivo inflammation model. Characterization of nanoparticles was carried out through TEM, DLS, FTIR Z-potential, and thermogravimetric tests. Macrophages were treated with MCM-41-PbAE and MCM-41-PbAE-DOX particles at several concentrations, and the production of proinflammatory and anti-inflammatory cytokines, nitric oxide (NO), and hydrogen peroxide (H

Indexed as

Anti-Inflammatory AgentsDoxorubicinEdemaNanoparticle Drug Delivery SystemAdministration, OralAnimalsAntibiotics, AntineoplasticCarrageenanCell SurvivalCytokinesDisease Models, AnimalHydrogen-Ion ConcentrationHydrogen PeroxideInflammation MediatorsMacrophagesMaleAntibiotics, AntineoplasticAnti-Inflammatory AgentsCarrageenanCytokinesDoxorubicinHydrogen PeroxideInflammation MediatorsMCM-41Nanoparticle Drug Delivery SystemNitric Oxidepoly(beta-amino ester)PolymersSilicon DioxideAnti-inflammatoryCytotoxicDoxorubicinDrug delivery systemsNano-vehicle

Identifiers

PMID40366401

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.