Evidence map›Paper›PMID 40367247›Full record

ArticleACS infectious diseases2025

Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi.

Satish R Malwal, Rocio Garcia-Rubio, Milena Kordalewska, Hoja Patterson, Chi Zhang, Jorge D Calderin, Ruijie Zhou, Akanksha M Pandey, Erika Shor, David S Perlin and 5 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Satish R MalwalDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-7606-1932
Rocio Garcia-RubioCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.
Milena KordalewskaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.
Hoja PattersonFungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Chi ZhangDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Jorge D CalderinDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Ruijie ZhouDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Akanksha M PandeyDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-8204-9558
Erika ShorCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.
Nathan P WiederholdFungus Testing Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Luis Ostrosky-ZeichnerDivision of Infectious Diseases, University of Texas Health Science Center, Houston, Texas 77030, United States.
Rutilio FrattiDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-9109-6666
Carol NacySequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, Maryland 20850, United States.
Eric OldfieldDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-0996-7352

Funding

Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
NIAID NIH HHS R01 AI109025
6 · The paper itself

Abstract

We investigated the activity of the tuberculosis drug SQ109 against 16 fungal pathogens:

Indexed as

Antifungal AgentsFungiMicrobial Sensitivity TestsReactive Oxygen SpeciesSaccharomyces cerevisiaeAntifungal AgentsReactive Oxygen SpeciesantifungalscalciumCandidaHistoplasmaprotonophorevacuoles

Identifiers

PMID40367247
PMCPMC12206483

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.