Evidence map›Paper›PMID 40367604›Full record

ArticleNeuroImage. Clinical2025

Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences.

James Lo, Jiaji Wang, Dylan Tran, Gabrielle Nemeh, Brandon Liu, Soo Hyun Shin, Jiyo S Athertya, Dawn Schiehser, Yajun Ma, Jiang Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James LoDepartment of Radiology, University of California, San Diego, CA, USA; Department of Bioengineering, University of California, San Diego, CA, USA.
Jiaji WangDepartment of Radiology, University of California, San Diego, CA, USA.
Dylan TranDepartment of Radiology, University of California, San Diego, CA, USA.
Gabrielle NemehDepartment of Radiology, University of California, San Diego, CA, USA.
Brandon LiuSchool of Medicine, University of California, San Diego, CA, USA.
Soo Hyun ShinDepartment of Radiology, University of California, San Diego, CA, USA.
Jiyo S AthertyaDepartment of Radiology, University of California, San Diego, CA, USA.
Dawn SchiehserResearch Service, Veterans Affairs San Diego Healthcare System (VASDHS), San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA.
Yajun MaDepartment of Radiology, University of California, San Diego, CA, USA.
Jiang DuDepartment of Radiology, University of California, San Diego, CA, USA; Department of Bioengineering, University of California, San Diego, CA, USA; Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. Electronic address: jiangdu@health.ucsd.edu.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's DiseaseRF1AG075717 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2022 to 2022
$2.3M
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's DiseaseR01AG075717 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jiang Du · 2025 to 2026
$1.3M
Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's diseaseF32AG082458 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ATHERTYA, JIYO S · 2023 to 2025
$256k
CSRD VA I01 CX002211NIAMS NIH HHS R01 AR079484NIA NIH HHS F32 AG082458NIA NIH HHS R01 AG075717NIA NIH HHS RF1 AG075717
6 · The paper itself

Abstract

Myelin proton density fraction (MPDF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of aging and neurodegeneration, but the effects of aging on MPDF/MWF remain unknown. This study aims to assess relationships between age and MPDF/MWF using the 3D STAIR ultrashort echo time (STAIR-UTE) and STAIR short echo time (STAIR-STE) sequences, respectively. 42 volunteers (29 young (<55y), 13 old (>55y)), were recruited for MPDF and MWF mapping for white matter (WM) and gray matter (GM) on a 3 T scanner. Excellent inter-reader reliability was demonstrated for MPDF and MWF measurements with ICC values of 0.97 and 0.98, respectively, between two readers. In the young group, WM MPDF and MWF range from 8-13 % and 6-13 %, respectively, while GM MPDF and MWF range from 5-7 % and 3-5 %, respectively. In the old group, WM MPDF and MWF range from 6-12 % and 5-13 %, and GM MPDF and MWF range from 3-6 % and 2-5 %, respectively. The young group's MPDF/MWF values were significantly higher than those of the old group. Altogether, the 42 volunteers display linear and quadratic associations of MPDF/MWF with age. MPDF demonstrated significant correlations with MWF in the majority of brain regions. This study demonstrates the capability of two myelin imaging biomarkers, STAIR-UTE measured MPDF and STAIR-STE measured MWF to map brain myelin and MW. These biomarkers hold the potential to differentiate normal aging from neuroinflammatory/neurodegenerative diseases.

Indexed as

AgingBrainMagnetic Resonance ImagingMyelin SheathAdultAgedFemaleGray MatterHumansMaleMiddle AgedWhite MatterYoung AdultAgingBiomarkerBrainMyelin contentMyelin water

Identifiers

PMID40367604
PMCPMC12140967

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.