ReviewFrontiers in neuroendocrinology2025
History of hypertensive disorders of pregnancy and risk of Alzheimer's disease and vascular dementia.
Review in Frontiers in neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Hypertension as a Major Risk Factor in Alzheimer's Disease: Mechanisms, Interactions and Therapeutic Perspectives.Clinical interventions in aging · 2026Review
- Maternal outcomes among women with intellectual disabilities in comparison with the general population (IDcare).AJOG global reports · 2025Article
- Women's health research funding in Canada across 15 years suggests low funding levels with a narrow focus.Biology of sex differences · 2025Article
- Previous parity differentially influences cognition in later life depending on dementia status.NPJ dementia · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The incidence of dementia, and specifically, Alzheimer's disease, is higher in women than men, even in middle age, making it possible to rule out lifespan differences between men and women as a contributing factor. Thus, it is plausible that pregnancy experience, which is unique to women, may play a contributing role. In this review, we discuss the different hypertensive disorders of pregnancy (HDP), Alzheimer's and vascular dementia, clinical, epidemiological, and preclinical studies that link a history of HDP with dementia. We also present potential mechanisms linking HDP, Alzheimer's, and vascular dementia. Several key symptoms that are shared among the disorders are presented as potential underlying mechanisms that link the adverse pregnancy disorder with the long-term postpartum neurological changes. Further, we present limitations of the existing literature, gaps, and opportunities for further research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.