Evidence map›Paper›PMID 40368121›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Toward a person-centered return of research results of dementia risk: A pluralistic, constructive expansion.

Bilal Irfan, Elijah Wiseman, J Wesley Boyd, Jonathan Reader, Annalise Rahman-Filipiak

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bilal IrfanCenter for Bioethics, Harvard Medical School, Boston, MA, USA.
Elijah WisemanCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA.
J Wesley BoydCenter for Bioethics, Harvard Medical School, Boston, MA, USA.
Jonathan ReaderMichigan Alzheimer's Disease Research Center, Ann Arbor, MI, USA.
Annalise Rahman-FilipiakMichigan Alzheimer's Disease Research Center, Ann Arbor, MI, USA.

Funding

Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nicholas M Kanaan · 2021 to 2026
$26.5M
DNA methylation in context: Racial inequities in social adversity and vulnerability to the health impact of air pollution - Diversity Supplement (Fike)R01AG074887 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKEN, MARGARET TAKAKO · 2021 to 2025
$3.4M
Behavioral Change Following Culturally-Informed Biomarker Disclosure in Alzheimer’s DiseaseK23AG070044 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAHMAN-FILIPIAK, ANNALISE · 2021 to 2025
$914k
NIA NIH HHS K23 AG070044NIA NIH HHS P30 AG072931NIA NIH HHS R01 AG074887
6 · The paper itself

Abstract

Graham et al.'s article offers a thoughtful account of why disclosing modifiable dementia risk factors to cognitively unimpaired research participants may be ethically defensible. In this Ethics Response, we seek to engage constructively with their arguments, affirming value in a person-centered approach, while also expanding on how cultural, communal, and religious contexts can further illuminate the ethics of returning individual research results. Drawing on emerging ethical issues and examples from diverse settings, this response highlights how stigmatization, religious worldviews, family care traditions, and broader socioeconomic factors may influence the perceived meaning and impact of dementia risk communication.

Indexed as

DementiaDisclosureHumansReturn of Individual Research ResultsRisk FactorsAlzheimer's diseasebrain healthcaregivingdelivery of health careethics

Identifiers

PMID40368121
PMCPMC12283226

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.